2019
Modulation of Gonadotropin-Releasing Hormone Neuron Activity and Secretion in Mice by Non-peptide Neurotransmitters, Gasotransmitters, and Gliotransmitters
Spergel DJ. Modulation of Gonadotropin-Releasing Hormone Neuron Activity and Secretion in Mice by Non-peptide Neurotransmitters, Gasotransmitters, and Gliotransmitters. Frontiers In Endocrinology 2019, 10: 329. PMID: 31178828, PMCID: PMC6538683, DOI: 10.3389/fendo.2019.00329.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGnRH neuron activityGnRH secretionNeuron activityNon-peptide neurotransmittersGnRH neuronsGonadotropin-Releasing Hormone Neuron ActivityMouse GnRH neuronsProstaglandin E2Central regulationAdult miceGliotransmittersMouse studiesNitric oxideSecretionNeurotransmittersDirect modulationMiceNeuronsGasotransmitterFurther explorationGonadotropinModulationActivityGABAPostnatal
2012
Effects of Leptin and Melanocortin Signaling Interactions on Pubertal Development and Reproduction
Israel DD, Sheffer-Babila S, de Luca C, Jo YH, Liu SM, Xia Q, Spergel DJ, Dun SL, Dun NJ, Chua SC. Effects of Leptin and Melanocortin Signaling Interactions on Pubertal Development and Reproduction. Endocrinology 2012, 153: 2408-2419. PMID: 22408174, PMCID: PMC3381095, DOI: 10.1210/en.2011-1822.Peer-Reviewed Original ResearchConceptsGnRH neuron activityNeuron activityGnRH neuronsFemale db/db miceDb/db miceMelanocortin 4 receptor activationNeuropeptides neuropeptide YAgouti-related peptideAction potential firingEffects of leptinC-fos expressionMelanocortin-4 receptorInitiation of pubertyHypothalamic hypogonadismDb miceNeuropeptide YMelanocortin agonistsLeptin receptorReceptor activationPubertal developmentΑ-MSHPubertal onsetMelanocortinLeptinDownstream mediator