2012
Midbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger
Nolan-Poupart S, Veldhuizen MG, Geha P, Small DM. Midbrain response to milkshake correlates with ad libitum milkshake intake in the absence of hunger. Appetite 2012, 60: 168-174. PMID: 23064394, PMCID: PMC3526000, DOI: 10.1016/j.appet.2012.09.032.Peer-Reviewed Original ResearchConceptsAbsence of hungerFunctional magnetic resonance imagingSubsequent intakeRatings of hungerPeriaqueductal gray regionMidbrain responsesMagnetic resonance imagingKey reward regionsPalatable milkshakeSignificant positive associationPalatable foodResonance imagingInsular responsesOrbitofrontal cortexNeural circuitsGreater intakeMilkshake consumptionIntakeReward regionsBrain responsesEnhanced responseMilkshakePositive associationMidbrainGray region
2011
Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food
Stice E, Yokum S, Burger KS, Epstein LH, Small DM. Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food. Journal Of Neuroscience 2011, 31: 4360-4366. PMID: 21430137, PMCID: PMC3260083, DOI: 10.1523/jneurosci.6604-10.2011.Peer-Reviewed Original ResearchConceptsNormal weight humansObese humansStriatal responsesFood intakeOrbitofrontal cortexDopamine signalingWeight gainInitial vulnerability factorsGenetic riskStriatal D2 receptorsMonetary rewardsNormal-weight adolescentsPalatable food intakeD2 receptor densityD2 receptorsHigh-risk youthParietal operculumReceptor densitySomatosensory regionsPalatable foodFoods contributesFrontal operculumReward circuitryReduced dopamineObesity
2008
Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele
Stice E, Spoor S, Bohon C, Small DM. Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele. Science 2008, 322: 449-452. PMID: 18927395, PMCID: PMC2681095, DOI: 10.1126/science.1161550.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesBasal GangliaBody Mass IndexCaudate NucleusCorpus StriatumCuesDeoxyribonucleases, Type II Site-SpecificDopamineEatingFemaleFoodHumansHyperphagiaMagnetic Resonance ImagingObesityPolymorphism, Restriction Fragment LengthPutamenReceptors, Dopamine D2Regression AnalysisRewardSignal TransductionWeight GainConceptsDorsal striatumTaqIA restriction fragment length polymorphismConsummatory food rewardMagnetic resonance imaging studyStriatal dopamine receptorsDevelopment of obesityA1 alleleResonance imaging studyFunctional magnetic resonance imaging studyDopamine D2 receptor geneTaqIA A1 alleleObese individualsStriatal dopamineD2 receptor geneProspective dataLean individualsDopamine receptorsFood intakeStriatumImaging studiesStriatal responsesStriatal activationGenetic polymorphismsReceptor geneObesity