2016
Effects of the modern food environment on striatal function, cognition and regulation of ingestive behavior
Burke MV, Small DM. Effects of the modern food environment on striatal function, cognition and regulation of ingestive behavior. Current Opinion In Behavioral Sciences 2016, 9: 97-105. PMID: 29619405, PMCID: PMC5879782, DOI: 10.1016/j.cobeha.2016.02.036.Peer-Reviewed Original ResearchFood cue reactivityCue reactivityWeight gain susceptibilityDorsal striatal dopamineEnergy-dense dietInhibitory controlModern food environmentChronic consumptionImpaired inhibitory controlStriatal dopamineStriatal functionStriatal circuitsAnimal studiesBody weightMetabolic diseasesDiet-induced adaptationsPalatable foodDense dietBrain functionIngestive behaviorFood environmentImpair inhibitory controlDietDeleterious influenceNegative outcomes
2008
Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele
Stice E, Spoor S, Bohon C, Small DM. Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele. Science 2008, 322: 449-452. PMID: 18927395, PMCID: PMC2681095, DOI: 10.1126/science.1161550.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesBasal GangliaBody Mass IndexCaudate NucleusCorpus StriatumCuesDeoxyribonucleases, Type II Site-SpecificDopamineEatingFemaleFoodHumansHyperphagiaMagnetic Resonance ImagingObesityPolymorphism, Restriction Fragment LengthPutamenReceptors, Dopamine D2Regression AnalysisRewardSignal TransductionWeight GainConceptsDorsal striatumTaqIA restriction fragment length polymorphismConsummatory food rewardMagnetic resonance imaging studyStriatal dopamine receptorsDevelopment of obesityA1 alleleResonance imaging studyFunctional magnetic resonance imaging studyDopamine D2 receptor geneTaqIA A1 alleleObese individualsStriatal dopamineD2 receptor geneProspective dataLean individualsDopamine receptorsFood intakeStriatumImaging studiesStriatal responsesStriatal activationGenetic polymorphismsReceptor geneObesity