2017
Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward
Veldhuizen MG, Babbs RK, Patel B, Fobbs W, Kroemer NB, Garcia E, Yeomans MR, Small DM. Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward. Current Biology 2017, 27: 2476-2485.e6. PMID: 28803868, PMCID: PMC5745144, DOI: 10.1016/j.cub.2017.07.018.Peer-Reviewed Original ResearchConceptsCaloric loadGreater metabolic responseNon-linear associationMetabolic responseSugar-sweetened beveragesBrain responsesLow-calorie beveragesHigh-calorie beveragesNon-nutritive sweetenersGreater brain responsePost-ingestive signalsHuman studiesSweet tasteNutrient metabolismCarbohydrate metabolismNovel mechanismBeveragesPotencyAssociationMetabolismCarbohydrate rewards
2015
Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism
Burke MV, Small DM. Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism. Physiology & Behavior 2015, 152: 381-388. PMID: 26048305, PMCID: PMC4661139, DOI: 10.1016/j.physbeh.2015.05.036.Peer-Reviewed Original ResearchConceptsNon-nutritive sweetenersNNS consumptionCognitive processesSugar-sweetened beverage consumptionNegative health outcomesMetabolic hormone secretionPotential biological mechanismsHormone secretionSSB intakeBody weightGut microbiotaSweet taste receptorBeverage consumptionHealth outcomesNNS useCentral mechanismsTaste receptorsBiological mechanismsMetabolic functionsPhysiological mechanismsMetabolismIntakeSecretionReceptors