2022
Dietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial
Fang X, Davis X, Flack KD, Duncan C, Li F, White M, Grilo C, Small DM. Dietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial. Frontiers In Nutrition 2022, 9: 940064. PMID: 35967820, PMCID: PMC9369668, DOI: 10.3389/fnut.2022.940064.Peer-Reviewed Original ResearchWeight loss maintenanceHigh-fat dietWeight loss treatmentLoss maintenanceWeight lossLoss treatmentStandard behavioral weight loss treatmentShort-term weight lossBehavioral weight loss interventionBehavioral weight loss treatmentGut-brain pathwaysPlacebo-controlled trialGut-brain axisVagal afferent pathwaysGut-brain signalingDietary fat intakeOverweight/obesityWeight loss interventionPrecision medicine approachEnergy-dense foodsLoss interventionFat intakeAfferent pathwaysHabitual intakeMetabolic health
2013
Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity
Babbs RK, Sun X, Felsted J, Chouinard-Decorte F, Veldhuizen MG, Small DM. Decreased caudate response to milkshake is associated with higher body mass index and greater impulsivity. Physiology & Behavior 2013, 121: 103-111. PMID: 23562867, PMCID: PMC3731396, DOI: 10.1016/j.physbeh.2013.03.025.Peer-Reviewed Original ResearchConceptsBody mass indexCaudate responseMass indexCaudate nucleusBrain responsesHigher body mass indexWeight gainHealthy weight subjectsTasteless control solutionEnergy-dense foodsSelf-reported impulsivityWeight subjectsNegative associationVentral putamenDorsal striatumFood rewardDense foodsSignificant associationInverse correlationMilkshakeOverweightGreater impulsivityMeasures of impulsivityGreater responseAssociation
2012
Altered hypothalamic response to food in smokers 1 , 2 , 3
Geha PY, Aschenbrenner K, Felsted J, O'Malley SS, Small DM. Altered hypothalamic response to food in smokers 1 , 2 , 3. American Journal Of Clinical Nutrition 2012, 97: 15-22. PMID: 23235196, PMCID: PMC3522134, DOI: 10.3945/ajcn.112.043307.Peer-Reviewed Original ResearchConceptsWeight changeBrain responsesFunctional MRILong-term weight changeAltered brain responsesTasteless control solutionMilk shakeEnergy-dense foodsGroup of ageSmoking statusSmoking cessationSmoking influencesHypothalamic responseNonsmokersSmokersVentral striatumWeight gainBMIHypothalamusGreater responseResponseFoodStudy 1ThalamusGroup
2009
Individual differences in the neurophysiology of reward and the obesity epidemic
Small DM. Individual differences in the neurophysiology of reward and the obesity epidemic. International Journal Of Obesity 2009, 33: s44-s48. PMID: 19528979, PMCID: PMC2788336, DOI: 10.1038/ijo.2009.71.Peer-Reviewed Original Research