2018
Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans
Thanarajah SE, Backes H, DiFeliceantonio AG, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Brüning JC, Tittgemeyer M. Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metabolism 2018, 29: 695-706.e4. PMID: 30595479, DOI: 10.1016/j.cmet.2018.12.006.Peer-Reviewed Original ResearchConceptsDopaminergic circuitsHigher cognitive centersSegregated brain regionsPeripheral physiological signalsPalatable food intakeReward valueDopamine releaseCognitive centersSubjective desireBrain regionsBrain areasUnderlying reinforcementFood intakeDorsal striatumRole of brainPhysiological signalsFood selection behaviorIntegrative pathwaysFMRIDesirePET methodBrainHumansIntakeSelection behavior
2003
Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers
Small DM, Jones-Gotman M, Dagher A. Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers. NeuroImage 2003, 19: 1709-1715. PMID: 12948725, DOI: 10.1016/s1053-8119(03)00253-2.Peer-Reviewed Original ResearchConceptsDopamine releasePositron emission tomography scanEmission tomography scanHealthy human volunteersHunger/fullnessFavorite mealAmount of dopamineDorsal putamenStriatum correlatesTomography scanHealthy subjectsCaudate nucleusPleasantness ratingsHuman volunteersVentral striatumScan subjectsStriatumHungry stateSignificant reductionSignificant changesPET dataMealParametric mapsSubjectsCorrelates