2012
HIV: Cell Binding and Entry
Wilen CB, Tilton JC, Doms RW. HIV: Cell Binding and Entry. Cold Spring Harbor Perspectives In Medicine 2012, 2: a006866. PMID: 22908191, PMCID: PMC3405824, DOI: 10.1101/cshperspect.a006866.Peer-Reviewed Original ResearchConceptsHIV entryViral tropismPrimary cellular receptor CD4Human immunodeficiency virus (HIV) replicationAbility of HIVImmunodeficiency virus replicationHost immune responseHuman immune systemCellular receptor CD4Immune responseCellular coreceptorTherapeutic interventionsImmune systemReceptor CD4Virus replicationHIVCell bindingHost cell cytoplasmTropismHost cell membraneTrigger fusionCell cytoplasmCD4Major rolePathogenesis
2011
Molecular Mechanisms of HIV Entry
Wilen CB, Tilton JC, Doms RW. Molecular Mechanisms of HIV Entry. Advances In Experimental Medicine And Biology 2011, 726: 223-242. PMID: 22297516, DOI: 10.1007/978-1-4614-0980-9_10.Peer-Reviewed Original ResearchConceptsHIV entryOnly viral surface proteinHuman immunodeficiency virus (HIV) entryHumoral immune responseMembrane fusion machineryCoreceptor-binding siteHost protein CD4Viral surface proteinsHIV infectionSmall molecule inhibitorsImmune responseChemokine coreceptorsFusion machineryViral tropismClinical treatmentVirus entryMolecular mechanismsHost cellsFacilitates exposureMolecule inhibitorsGp41 subunitSurface proteinsViral genomeAmino acidsCD4