2000
Divergent homeobox gene Hex regulates promoter of the Na+-dependent bile acid cotransporter
Denson L, Karpen S, Bogue C, Jacobs H. Divergent homeobox gene Hex regulates promoter of the Na+-dependent bile acid cotransporter. AJP Gastrointestinal And Liver Physiology 2000, 279: g347-g355. PMID: 10915644, DOI: 10.1152/ajpgi.2000.279.2.g347.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCarrier ProteinsCOS CellsGene Expression RegulationGenetic Complementation TestHepatoblastomaHomeodomain ProteinsHumansLiverLiver NeoplasmsMembrane Transport ProteinsMolecular Sequence DataMutagenesisOligonucleotide ProbesOrganic Anion Transporters, Sodium-DependentPromoter Regions, GeneticRatsRecombinant Fusion ProteinsSymportersTranscription FactorsTranscription, GeneticTumor Cells, CulturedConceptsHomeobox gene HexDivergent homeobox gene HexNtcp promoterHex proteinHep G2 cellsElectrophoretic mobility shift assaysMobility shift assaysHeterologous promoter constructsDominant-negative formG2 cellsSpecific nuclear proteinLuciferase reporter constructsNuclear proteinsGene promoterShift assaysCOS cellsBasal luciferase activityReporter constructsPromoter regionBile acid cotransporterPromoter constructsResponse elementNegative formPromoterAcid cotransporterHNF3β and GATA-4 transactivate the liver-enriched homeobox gene, Hex
Denson L, McClure M, Bogue C, Karpen S, Jacobs H. HNF3β and GATA-4 transactivate the liver-enriched homeobox gene, Hex. Gene 2000, 246: 311-320. PMID: 10767553, DOI: 10.1016/s0378-1119(00)00082-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCOS CellsDNADNA-Binding ProteinsGATA4 Transcription FactorGenes, HomeoboxHepatocyte Nuclear Factor 3-betaHomeodomain ProteinsHumansLiverLuciferasesMaleMiceMolecular Sequence DataNuclear ProteinsPlasmidsPromoter Regions, GeneticProtein BindingRatsRats, Sprague-DawleyRecombinant Fusion ProteinsSequence Analysis, DNASp1 Transcription FactorSp3 Transcription FactorTranscription FactorsTranscriptional ActivationTransfectionTumor Cells, Cultured
1999
Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex
Ghosh B, Jacobs H, Wiedemann L, Brown A, Bedford F, Nimmakayalu M, Ward D, Bogue C. Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex. Mammalian Genome 1999, 10: 1023-1025. PMID: 10501975, DOI: 10.1007/s003359901152.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBase SequenceChromosome MappingCloning, MolecularCrosses, GeneticGenes, HomeoboxGenetic LinkageGenetic MarkersHomeodomain ProteinsIn Situ Hybridization, FluorescenceLiverMiceMice, Inbred StrainsMolecular Sequence DataRestriction MappingSequence AnalysisTranscription Factors