2000
Divergent homeobox gene Hex regulates promoter of the Na+-dependent bile acid cotransporter
Denson L, Karpen S, Bogue C, Jacobs H. Divergent homeobox gene Hex regulates promoter of the Na+-dependent bile acid cotransporter. AJP Gastrointestinal And Liver Physiology 2000, 279: g347-g355. PMID: 10915644, DOI: 10.1152/ajpgi.2000.279.2.g347.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCarrier ProteinsCOS CellsGene Expression RegulationGenetic Complementation TestHepatoblastomaHomeodomain ProteinsHumansLiverLiver NeoplasmsMembrane Transport ProteinsMolecular Sequence DataMutagenesisOligonucleotide ProbesOrganic Anion Transporters, Sodium-DependentPromoter Regions, GeneticRatsRecombinant Fusion ProteinsSymportersTranscription FactorsTranscription, GeneticTumor Cells, CulturedConceptsHomeobox gene HexDivergent homeobox gene HexNtcp promoterHex proteinHep G2 cellsElectrophoretic mobility shift assaysMobility shift assaysHeterologous promoter constructsDominant-negative formG2 cellsSpecific nuclear proteinLuciferase reporter constructsNuclear proteinsGene promoterShift assaysCOS cellsBasal luciferase activityReporter constructsPromoter regionBile acid cotransporterPromoter constructsResponse elementNegative formPromoterAcid cotransporter
1998
Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats
Jacobs H, Bogue C, Pinter E, Wilson C, Warshaw J, Gross I. Fetal Lung mRNA Levels of Hox Genes Are Differentially Altered by Maternal Diabetes and Butyrate in Rats. Pediatric Research 1998, 44: 99-104. PMID: 9667378, DOI: 10.1203/00006450-199807000-00016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsButyratesButyric AcidDiabetes Mellitus, ExperimentalEmbryonic and Fetal DevelopmentFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxGestational AgeHistone Deacetylase InhibitorsLungOrgan Culture TechniquesPregnancyPregnancy in DiabeticsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsLung developmentLung explantsSurfactant apoproteinExperimental animalsLung mRNA levelsElevated levelsEffect of diabetesFetal rat lung explantsLungs of fetusesRat lung explantsEffect of butyrateAntenatal exposureMaternal diabetesMetabolic abnormalitiesStreptozotocin treatmentLower incidenceNormal ratsDiabetesDexamethasoneLevel of expressionRatsTreatment of explantsSodium butyrateMRNA levelsAlters expression