2021
Progranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitus
Ding Y, Wei J, Hettinghouse A, Li G, Li X, Einhorn T, Liu C. Progranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitus. Annals Of The New York Academy Of Sciences 2021, 1490: 77-89. PMID: 33543485, PMCID: PMC8138780, DOI: 10.1111/nyas.14568.Peer-Reviewed Original ResearchConceptsType 2 diabetes mellitusRole of progranulinBone fracture healingFracture healingDiabetes mellitusT2DM modelType 1 diabetic conditionAnti-inflammatory activityTranscription-polymerase chain reactionLocal administrationBone marrow cellsExogenous progranulinMKR micePGRN effectsPrimary bone marrow cellsFracture riskDiabetic conditionsPGRN mRNABone fragilityImmunohistochemical stainingMetabolic disordersRecombinant progranulinBone fracturesProgranulinTherapeutic potential
2019
Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review.
Chen Y, Liu R, Hettinghouse A, Wang S, Liu G, Liu C. Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review. JBJS Reviews 2019, 7: e10. PMID: 30694878, DOI: 10.2106/jbjs.rvw.18.00052.Peer-Reviewed Original ResearchConceptsNonvertebral fracturesParathyroid hormoneFracture preventionOsteoporotic patientsSystematic reviewSelective estrogen receptor modulatorsChronic kidney diseaseSystematic Reviews 2Estrogen receptor modulatorsPostmenopausal statusAdverse eventsRANKL inhibitorGlucocorticoid treatmentOvid EmbaseCochrane LibraryKidney diseaseFracture riskEligible studiesStrontium ranelateOvid MEDLINEReceptor modulatorsTeriparatideOsteoporotic individualsHigh riskAnabolic agents