2022
Are infections associated with cognitive decline and neuroimaging outcomes? A historical cohort study using data from the UK Biobank study linked to electronic health records
Muzambi R, Bhaskaran K, Rentsch C, Smeeth L, Brayne C, Garfield V, Williams D, Chaturvedi N, Warren-Gash C. Are infections associated with cognitive decline and neuroimaging outcomes? A historical cohort study using data from the UK Biobank study linked to electronic health records. Translational Psychiatry 2022, 12: 385. PMID: 36109502, PMCID: PMC9478085, DOI: 10.1038/s41398-022-02145-z.Peer-Reviewed Original ResearchConceptsCognitive declineWhite matter hyperintensity volumeSecondary care recordsAssociation of infectionHistory of infectionPotential structural correlatesEvidence of associationCommon infectionsDementia riskHyperintensity volumeInfection diagnosisCare recordsCognitive impairmentLinear mixed effects modelsCognitive functionVolunteer cohortInfectionMixed effects modelsStructural correlatesUK BiobankLinear regression modelsAssociationEffects modelRegression modelsVisual memory
2021
Relationship Between Glycemia and Cognitive Function, Structural Brain Outcomes, and Dementia: A Mendelian Randomization Study in the UK Biobank.
Garfield V, Farmaki AE, Fatemifar G, Eastwood SV, Mathur R, Rentsch CT, Denaxas S, Bhaskaran K, Smeeth L, Chaturvedi N. Relationship Between Glycemia and Cognitive Function, Structural Brain Outcomes, and Dementia: A Mendelian Randomization Study in the UK Biobank. Diabetes 2021, 70: 2313-2321. PMID: 33632741, DOI: 10.2337/db20-0895.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiological Specimen BanksBlood GlucoseBrainCognitionDementiaDiabetes Mellitus, Type 2FemaleGenome-Wide Association StudyGlycated HemoglobinHumansMaleMemoryMendelian Randomization AnalysisMiddle AgedOrgan SizePolymorphism, Single NucleotidePrognosisReaction TimeRisk FactorsUnited KingdomWhite MatterConceptsWhite matter hyperintensity volumeType 2 diabetesHippocampal volumeAlzheimer's dementiaRisk of ADCognitive functionMendelian randomizationBrain structuresStructural brain outcomesGenetic instrumentsMR sensitivity analysesUK BiobankVisual memoryMendelian randomization studyIncident dementiaBrain outcomesDiabetes riskHyperintensity volumeMeasures of cognitionPeripheral glycemiaBidirectional Mendelian randomizationDiabetesRandomization studyCausal associationGlycemia
2020
Risk of 16 cancers across the full glycemic spectrum: a population-based cohort study using the UK Biobank
Rentsch CT, Farmer RE, Eastwood SV, Mathur R, Garfield V, Farmaki AE, Bhaskaran K, Chaturvedi N, Smeeth L. Risk of 16 cancers across the full glycemic spectrum: a population-based cohort study using the UK Biobank. BMJ Open Diabetes Research & Care 2020, 8: e001600. PMID: 32859587, PMCID: PMC7454242, DOI: 10.1136/bmjdrc-2020-001600.Peer-Reviewed Original ResearchConceptsCancer riskGlycemic spectrumIncident cancerPancreatic cancerBreast cancerPopulation-based cohort studyAge-standardized incidence ratesCox proportional hazards modelPostmenopausal breast cancerPremenopausal breast cancerHistory of cancerIndependent positive associationProportional hazards modelUK cancer registriesUK BiobankEdition diagnostic codesBaseline HbA1cDiabetes medicationsMultivariable adjustmentCohort studyCancer RegistryRisk factorsDiagnostic codesIncidence rateInverse association