2022
Are infections associated with cognitive decline and neuroimaging outcomes? A historical cohort study using data from the UK Biobank study linked to electronic health records
Muzambi R, Bhaskaran K, Rentsch C, Smeeth L, Brayne C, Garfield V, Williams D, Chaturvedi N, Warren-Gash C. Are infections associated with cognitive decline and neuroimaging outcomes? A historical cohort study using data from the UK Biobank study linked to electronic health records. Translational Psychiatry 2022, 12: 385. PMID: 36109502, PMCID: PMC9478085, DOI: 10.1038/s41398-022-02145-z.Peer-Reviewed Original ResearchConceptsCognitive declineWhite matter hyperintensity volumeSecondary care recordsAssociation of infectionHistory of infectionPotential structural correlatesEvidence of associationCommon infectionsDementia riskHyperintensity volumeInfection diagnosisCare recordsCognitive impairmentLinear mixed effects modelsCognitive functionVolunteer cohortInfectionMixed effects modelsStructural correlatesUK BiobankLinear regression modelsAssociationEffects modelRegression modelsVisual memory
2021
UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records
Walker JL, Grint DJ, Strongman H, Eggo RM, Peppa M, Minassian C, Mansfield KE, Rentsch CT, Douglas IJ, Mathur R, Wong AYS, Quint JK, Andrews N, Bernal JL, Scott JA, Ramsay M, Smeeth L, McDonald HI. UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records. BMC Public Health 2021, 21: 484. PMID: 33706738, PMCID: PMC7948667, DOI: 10.1186/s12889-021-10427-2.Peer-Reviewed Original ResearchConceptsSevere COVID-19Health conditionsElectronic health recordsHigh riskRisk populationsCOVID-19Clinical Practice Research Datalink GOLDSevere COVID-19 diseaseSecondary care recordsChronic kidney diseaseHealth recordsChronic liver diseasePoint prevalence studyBinomial exact confidence intervalsOlder age groupsPublic health interventionsWorking-aged individualsCOVID-19 diseaseWorking-aged adultsUK prevalenceCurrent asthmaLiver diseaseCancer survivorsPoint prevalenceKidney disease