2018
Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease.
Won CHJ, Qin L, Selim B, Yaggi HK. Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease. Journal Of Clinical Sleep Medicine 2018, 14: 1987-1994. PMID: 30518445, PMCID: PMC6287733, DOI: 10.5664/jcsm.7520.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHypopnea definitionsDesaturation criteriaOdds ratioCardiovascular diseaseOSA diagnosisSeverity of OSAModerate obstructive sleep apneaSevere obstructive sleep apneaDifferent hypopnea definitionsLess smoking historySleep-disordered breathingIschemic heart diseaseSignificant risk factorsCross-sectional analysisArousal definitionHypopnea criteriaCardiovascular riskOSA severitySmoking historyHeart failureClinical featuresSleep apneaOSA groupRisk factors
2016
The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study.
Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.Peer-Reviewed Original ResearchConceptsSleep-disordered breathingNocturnal cardiac arrhythmiasIntraventricular conduction delayApnea-hypopnea indexCardiac arrhythmiasTwo-fold oddsModerate-severe sleep-disordered breathingSeverity of SDBSevere sleep-disordered breathingComplex ventricular ectopyMultiple cardiovascular comorbiditiesObstructive respiratory eventsClinic-based populationCross-sectional analysisCardiovascular comorbiditiesSDB patientsVentricular ectopySDB severityRespiratory eventsUnadjusted oddsSupraventricular tachycardiaCardiovascular diseaseArrhythmia subtypesArrhythmia riskConduction delay
2015
The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods
Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.Peer-Reviewed Original ResearchConceptsCardiovascular outcomesVascular eventsSleep architecturePrognostic modelRetrospective observational cohort studyMain primary outcomeMiddle-aged veteransTransient ischemic attackAcute coronary syndromeObservational cohort studyResultsThe study populationCongestive heart failureSleep-disordered breathingVA Patient Treatment FileVital Status filesPatient Treatment FileComputerized patient record systemVeterans Affairs centersPost-traumatic stress disorderIschemic attackCoronary syndromeCohort studySecondary outcomesComposite endpointGlycemic control