The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells
Cho C, Horzempa C, Jones D, McKeown-Longo PJ. The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells. BMC Cancer 2016, 16: 574. PMID: 27484721, PMCID: PMC4970220, DOI: 10.1186/s12885-016-2621-6.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Non-Small-Cell LungCaspase 8Cell Line, TumorCell SurvivalDrug Resistance, NeoplasmFibronectin Type III DomainFibronectinsGene Expression Regulation, NeoplasticHumansLung NeoplasmsPhosphatidylinositol 3-KinasesProtein FoldingProto-Oncogene Proteins c-aktReceptors, VitronectinSignal TransductionTNF-Related Apoptosis-Inducing LigandVitronectinConceptsType III domainLung cancer cellsUnfolded domainsTRAIL resistancePI3-kinase/AktSerine/threonine kinase pathwaysCancer cellsMulti-modular proteinThreonine kinase pathwaysNCI-H460 lung cancer cellsFnIII-1cFirst Type III domainNon-small cell lung cancer cellsTRAIL-induced apoptosisΑvβ5 integrin receptorLung cancer resistanceCell lung cancer cellsHuman lung cancer cellsKinase pathwayCancer cell resistanceIntegrin activationCaspase-8Signaling pathwaysFibronectin matrixSensitive proteins