2020
Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells
Cho C, Horzempa C, Longo CM, Peters DM, Jones DM, McKeown-Longo PJ. Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells. Journal Of Cancer 2020, 11: 3099-3105. PMID: 32231714, PMCID: PMC7097952, DOI: 10.7150/jca.39771.Peer-Reviewed Original ResearchType III domainExtracellular matrixLung cancer cellsFibronectin type III domainTumor-associated extracellular matrixCancer cellsFibronectin-rich extracellular matrixTLR4-dependent inflammatory responsesRich extracellular matrixFirst Type III domainIL-8Secondary structureStrained conformationMatrix fibronectinNF-κB pathwayEssential roleFibrotic microenvironmentTumor metastasisPathwayConformational labilityStromal cellsTumor progressionCytokine releaseLung cancerInflammatory response
2016
The Fibronectin III‐1 Domain Activates a PI3‐Kinase/Akt Signaling Pathway Leading to αvβ5 Integrin Activation and TRAIL Resistance in Human Lung Cancer Cells
Cho C, McKeown‐Longo P. The Fibronectin III‐1 Domain Activates a PI3‐Kinase/Akt Signaling Pathway Leading to αvβ5 Integrin Activation and TRAIL Resistance in Human Lung Cancer Cells. The FASEB Journal 2016, 30: lb82-lb82. DOI: 10.1096/fasebj.30.1_supplement.lb82.Peer-Reviewed Original ResearchLung cancer cellsTRAIL resistanceNon-small cell lung cancerH460 lung cancer cellsCancer cellsCell lung cancerHuman lung cancer cellsLung cancer resistancePI3K/Akt pathwayTumor-stroma interfaceCancer cell resistanceAkt Signaling PathwayΑvβ5 integrin receptorLung cancerImmunohistochemical stainingTumor stromaFirst Type III domainFnIII-1cDrug resistanceBlood vesselsAkt pathwayCancer resistanceSignaling pathwaysFibronectin contributesSubsequent apoptosis