Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells
Cho C, Horzempa C, Longo CM, Peters DM, Jones DM, McKeown-Longo PJ. Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells. Journal Of Cancer 2020, 11: 3099-3105. PMID: 32231714, PMCID: PMC7097952, DOI: 10.7150/jca.39771.Peer-Reviewed Original ResearchType III domainExtracellular matrixLung cancer cellsFibronectin type III domainTumor-associated extracellular matrixCancer cellsFibronectin-rich extracellular matrixTLR4-dependent inflammatory responsesRich extracellular matrixFirst Type III domainIL-8Secondary structureStrained conformationMatrix fibronectinNF-κB pathwayEssential roleFibrotic microenvironmentTumor metastasisPathwayConformational labilityStromal cellsTumor progressionCytokine releaseLung cancerInflammatory response