2024
Sex Differences in Hypertension and Its Management Throughout Life.
Yeo W, Abraham R, Surapaneni A, Schlosser P, Ballew S, Ozkan B, Flaherty C, Yu B, Bonventre J, Parikh C, Kimmel P, Vasan R, Coresh J, Grams M. Sex Differences in Hypertension and Its Management Throughout Life. Hypertension 2024 PMID: 39229711, DOI: 10.1161/hypertensionaha.124.22980.Peer-Reviewed Original ResearchPrevalence of hypertensionUncontrolled hypertensionChronic kidney disease progressionPrevalence of uncontrolled hypertensionKidney disease progressionBody mass indexClasses of medicationsSex differencesEstimate sex differencesCoronary heart diseaseHeart failureMass indexAntihypertensive medicationsDisease progressionStudy visitsAtherosclerosis RiskHypertensionHigh riskHypertensive individualsHeart diseaseLife courseCommunity studiesPrevalenceMedicationKidney Transplant Outcomes From Deceased Donors Who Received Dialysis
Wen Y, Mansour S, Srialluri N, Hu D, Philbrook H, Hall I, Doshi M, Mohan S, Reese P, Parikh C. Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis. JAMA 2024, 332: 215-225. PMID: 38780515, PMCID: PMC11117155, DOI: 10.1001/jama.2024.8469.Peer-Reviewed Original ResearchDeath-censored graft failureKidney transplant recipientsGraft failureDeceased kidney donorsKidney transplantationTransplant recipientsGraft functionDeceased donorsFollow-upHigher risk of delayed graft functionIncidence of delayed graft functionOutcomes of transplant recipientsRisk of delayed graft functionMedian follow-upKidney donorsDelayed graft functionUS organ procurement organizationsKidney transplant outcomesRetrospective cohort studyRecipients of kidneysKidney donationAcute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function
Bhatraju P, Zelnick L, Stanaway I, Ikizler T, Menez S, Chinchilli V, Coca S, Kaufman J, Kimmel P, Parikh C, Go A, Siew E, Wurfel M, Himmelfarb J. Acute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function. Clinical Journal Of The American Society Of Nephrology 2024, 19: 829-836. PMID: 38728094, PMCID: PMC11254015, DOI: 10.2215/cjn.0000000000000473.Peer-Reviewed Original ResearchConceptsLong-term cognitive impairmentRisk of long-term cognitive impairmentCognitive impairmentCognitive functionCognitive declineSoluble TNF receptor-1 concentrationsAssociated with poorer cognitive functionModified Mini-Mental Status ExaminationLong-term cognitive functionPoorer cognitive functionMini-Mental Status ExaminationLong-term cognitive declineSystemic inflammationCognitive testsCognitive dysfunctionSerial evaluationMediation analysisPersistent systemic inflammationSystemic inflammatory biomarkersAcute kidney injuryBaseline kidney functionComplication of CKDAssociated with long-term cognitive declineEpisode of AKITNF receptor 1Systematic Review and Meta-Analysis of Urine Neutrophil Gelatinase–Associated Lipocalin for Acute Kidney Injury in Cirrhosis
Puthumana J, Lugon N, Xu Y, Deng Y, Mistry P, Parikh C, Consortium T, Angeli P, Belcher J, Gambino C, Salaheldin M, Treepraertsuk S. Systematic Review and Meta-Analysis of Urine Neutrophil Gelatinase–Associated Lipocalin for Acute Kidney Injury in Cirrhosis. Kidney International Reports 2024, 9: 2278-2281. PMID: 39081737, PMCID: PMC11284356, DOI: 10.1016/j.ekir.2024.04.050.Peer-Reviewed Original ResearchUrine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies
Amatruda J, Katz R, Rebholz C, Sarnak M, Gutierrez O, Schrauben S, Greenberg J, Coresh J, Cushman M, Waikar S, Parikh C, Schelling J, Jogalekar M, Bonventre J, Vasan R, Kimmel P, Ix J, Shlipak M, Consortium C. Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies. Kidney Medicine 2024, 6: 100834. PMID: 38826568, PMCID: PMC11141432, DOI: 10.1016/j.xkme.2024.100834.Peer-Reviewed Original ResearchAssociated with incident chronic kidney diseaseIncident chronic kidney diseaseChronic kidney diseaseUrine MCP-1Meta-analysisUrine biomarkersMCP-1A1M concentrationsMultivariable Cox proportional hazards regressionRisk of chronic kidney diseaseRisk of incident chronic kidney diseaseCox proportional hazards regressionIndependent of eGFRPrevalent chronic kidney diseaseCohort of adultsMeta-analysis of resultsA1MLong follow-up periodEarly chronic kidney diseaseFollow-up periodProportional hazards regressionUrine A1MARIC participantsREGARDS studyHealth markersThe development of lateral flow devices for urinary biomarkers to assess kidney health
D Souza S, Obeid W, Hernandez J, Hu D, Wen Y, Moledina D, Albert A, Gregg A, Wheeler A, Philbrook H, Parikh C. The development of lateral flow devices for urinary biomarkers to assess kidney health. Scientific Reports 2024, 14: 8516. PMID: 38609491, PMCID: PMC11014899, DOI: 10.1038/s41598-024-59104-5.Peer-Reviewed Original ResearchConceptsLateral flow deviceInterleukin-9Development of lateral flow devicesUrinary biomarkersDetection antibody concentrationSerum creatinine levelsKidney healthPaired antibodiesEnzyme Linked Immunosorbent AssayCreatinine levelsKidney injuryKidney functionOsteopontinImmunosorbent assayAntibody concentrationsMeasured biomarkersKidneyReal-time changesBiomarkersAre biomarkers in acute kidney injury ready for prime time? The time is right for a second look
Parikh C, Coca S. Are biomarkers in acute kidney injury ready for prime time? The time is right for a second look. Kidney International 2024, 105: 675-678. PMID: 38519236, DOI: 10.1016/j.kint.2024.01.018.Peer-Reviewed Original ResearchThe authors reply
Hu D, Menez S, Thiessen-Philbrook H, Parikh C. The authors reply. Kidney International 2024, 105: 391. PMID: 38245219, DOI: 10.1016/j.kint.2023.10.026.Peer-Reviewed Original ResearchPHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS.
Parikh C, Hernandez J. PHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS. Transactions Of The American Clinical And Climatological Association 2024, 134: 37-46. PMID: 39135588, PMCID: PMC11316880.Peer-Reviewed Original ResearchConceptsAcute kidney injuryChronic kidney diseaseKidney injuryEpisodes of acute kidney injuryAssociated with long-term riskLong-term risk of readmissionLong-term sequelaeRepair biomarkersRisk of readmissionSubclinical inflammationPreclinical studiesUrine biomarkersResearch biopsiesDeceased donor kidneysClinical trialsKidney diseaseBlood pressureMedical managementDonor kidneysPragmatic clinical trialsKidney tissueTherapeutic developmentOrgan allocationPrecision medicineKidney
2023
Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Results From the African American Study of Kidney Disease and Hypertension (AASK) Trial
Chen T, Estrella M, Appel L, Surapaneni A, Köttgen A, Obeid W, Parikh C, Grams M. Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Results From the African American Study of Kidney Disease and Hypertension (AASK) Trial. American Journal Of Kidney Diseases 2023, 83: 71-78. PMID: 37690632, DOI: 10.1053/j.ajkd.2023.05.017.Peer-Reviewed Original ResearchConceptsRisk of kidney failureChronic kidney diseaseAssociated with mortalityKidney diseaseKidney failureRisk of KFRTSerum uromodulinCohort of African American adultsReplacement therapyUromodulin levelsHigh riskUrine protein-creatinine ratioAfrican American adultsStored serum samplesGlomerular filtration rateBlood pressure goalsProtein-creatinine ratioAbstractText Label="RESULTS">Levels of uromodulinStudy of Kidney DiseaseAfrican American Study of Kidney DiseaseRandomized treatment groupsAssociation of baselineBaseline demographic factorsCox proportional hazardsPlasma Biomarkers and Incident CKD Among Individuals Without Diabetes
Le D, Chen J, Shlipak M, Ix J, Sarnak M, Gutierrez O, Schelling J, Bonventre J, Sabbisetti V, Schrauben S, Coca S, Kimmel P, Vasan R, Grams M, Parikh C, Coresh J, Rebholz C, Consortium C. Plasma Biomarkers and Incident CKD Among Individuals Without Diabetes. Kidney Medicine 2023, 5: 100719. PMID: 37841418, PMCID: PMC10568645, DOI: 10.1016/j.xkme.2023.100719.Peer-Reviewed Original ResearchSoluble urokinase plasminogen activator receptorKidney injury molecule-1Incident chronic kidney diseaseChronic kidney diseaseLevels of kidney injury molecule-1Development of kidney diseaseMonocyte chemoattractant protein-1Kidney diseaseTNFR-2TNFR-1Development of chronic kidney diseaseConcentrations of kidney injury molecule-1Odds of incident chronic kidney diseaseAssociated with incident chronic kidney diseaseTumor necrosis factor receptor 2Urokinase plasminogen activator receptorCases of incident CKDYears of follow-upTumor necrosis factor receptor 1AbstractText Label="PLAIN-LANGUAGE SUMMARYBaseline plasma biomarkersHuman cartilage glycoprotein-39Kidney disease progressionPlasminogen activator receptorChemoattractant protein-1Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus
Vasquez-Rios G, Katz R, Levitan E, Cushman M, Parikh C, Kimmel P, Bonventre J, Waikar S, Schrauben S, Greenberg J, Sarnak M, Ix J, Shlipak M, Gutierrez O. Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus. Kidney360 2023, 4: e1257-e1264. PMID: 37533144, PMCID: PMC10547219, DOI: 10.34067/kid.0000000000000226.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Monocyte chemoattractant protein-1Kidney tubule healthCause-specific mortalityUrine biomarkersYKL-40Risk factorsCardiovascular deathCause mortalityHigh riskChitinase-3-like protein 1Greater riskHigher MCP-1Higher urine levelsUrine KIM-1Injury molecule-1Cause-specific deathMortality risk factorsProportional hazards regressionRisk of deathAdditional risk factorsProtein 1Cancer-related deathChemoattractant protein-1Alpha-1-microglobulinIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.Peer-Reviewed Original ResearchConceptsUrinary CXCL9External validation cohortValidation cohortControl groupAIN diagnosisDiscovery cohortKidney tissueDiagnostic biomarkersAcute interstitial nephritisCXCL9 mRNA expressionAcute kidney injuryBiopsy-confirmed diagnosisAvailable clinical testsNational InstituteKidney injuryTubulointerstitial nephritisInterstitial nephritisKidney biopsyHistological confirmationHistological diagnosisTreatment optionsLymphocyte chemotaxisCXCL9MRNA expression differencesPatients
2022
Kidney Tubule Injury and Dysfunction Biomarkers and Risk of Incident Hypertension in Community-Living Individuals: Results From the Multi-Ethnic Study of Atherosclerosis
Malhotra R, Katz R, Kimmel P, Ramachandran V, Al-Rousan T, Greenberg J, Parikh C, Bonventre J, Schelling J, Sarnak M, Gutierrez O, Shlipak M, Ix J. Kidney Tubule Injury and Dysfunction Biomarkers and Risk of Incident Hypertension in Community-Living Individuals: Results From the Multi-Ethnic Study of Atherosclerosis. Journal Of The American Society Of Nephrology 2022, 33: 529-529. DOI: 10.1681/asn.20223311s1529a.Peer-Reviewed Original ResearchAssociations of Baseline and Longitudinal Uromodulin With ESKD and Mortality: Results From the AASK Trial
Chen T, Estrella M, Appel L, Surapaneni A, Kottgen A, Obeid W, Parikh C, Grams M. Associations of Baseline and Longitudinal Uromodulin With ESKD and Mortality: Results From the AASK Trial. Journal Of The American Society Of Nephrology 2022, 33: 574-574. DOI: 10.1681/asn.20223311s1574a.Peer-Reviewed Original Research
2021
Comparison of Proteomic Methods in Evaluating Biomarker-AKI Associations in Cardiac Surgery Patients
Liu R, Philbrook H, Ramachandran V, Coresh J, Ganz P, Bonventre J, Kimmel P, Parikh C. Comparison of Proteomic Methods in Evaluating Biomarker-AKI Associations in Cardiac Surgery Patients. Journal Of The American Society Of Nephrology 2021, 32: 591-591. DOI: 10.1681/asn.20213210s1591a.Peer-Reviewed Original ResearchComparison of Aptamer-Based and Antibody-Based Assays for Protein Quantification in CKD
Lopez-Silva C, Surapaneni A, Coresh J, Reiser J, Appel L, Parikh C, Obeid W, Grams M, Chen T. Comparison of Aptamer-Based and Antibody-Based Assays for Protein Quantification in CKD. Journal Of The American Society Of Nephrology 2021, 32: 592-592. DOI: 10.1681/asn.20213210s1592a.Peer-Reviewed Original Research
2016
Kidney Outcomes 5 Years After Pediatric Cardiac Surgery: The TRIBE-AKI Study
Greenberg JH, Zappitelli M, Devarajan P, Thiessen-Philbrook HR, Krawczeski C, Li S, Garg AX, Coca S, Parikh CR. Kidney Outcomes 5 Years After Pediatric Cardiac Surgery: The TRIBE-AKI Study. JAMA Pediatrics 2016, 170: 1071-1078. PMID: 27618162, PMCID: PMC5476457, DOI: 10.1001/jamapediatrics.2016.1532.Peer-Reviewed Original ResearchConceptsLong-term kidney outcomesAcute kidney injuryChronic kidney diseasePediatric cardiac surgeryPerioperative acute kidney injuryPostoperative acute kidney injuryCardiac surgeryKidney diseaseKidney outcomesKidney injuryHigh short-term morbidityProspective multicenter cohort studySerum creatinine riseMulticenter cohort studyShort-term morbidityAge 1 monthOutcomes 5 yearsRenal outcomesPreoperative baselineCohort studyPediatric centersCardiopulmonary bypassCreatinine risePerson followPerson visitsA Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury
Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. American Journal Of Respiratory And Critical Care Medicine 2016, 195: 482-490. PMID: 27576016, PMCID: PMC5378420, DOI: 10.1164/rccm.201603-0518oc.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedApolipoprotein L1ApolipoproteinsBiomarkersCardiac Surgical ProceduresCase-Control StudiesCritical IllnessFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansIntensive Care UnitsInterferon Regulatory Factor-2Lipoproteins, HDLMaleMiddle AgedPolymorphism, Single NucleotidePostoperative ComplicationsRisk FactorsStatistics, NonparametricT-Box Domain ProteinsConceptsAcute kidney injuryGenome-wide association studiesSingle nucleotide polymorphismsKidney injuryGenetic lociAssociation studiesExploratory genome-wide association studyAcute kidney injury casesHospital acute kidney injuryCommon genetic variantsIndependent lociGene TBX1Chromosome 4Novel pathwayCritical illnessCardiac surgerySevere complicationsLociPatient populationTherapeutic advancesGenetic variantsGenotype imputationInjury casesExpedite recoveryInjuryYKL-40 Associates with Renal Recovery in Deceased Donor Kidney Transplantation
Puthumana J, Hall IE, Reese PP, Schröppel B, Weng FL, Thiessen-Philbrook H, Doshi MD, Rao V, Lee CG, Elias JA, Cantley LG, Parikh CR. YKL-40 Associates with Renal Recovery in Deceased Donor Kidney Transplantation. Journal Of The American Society Of Nephrology 2016, 28: 661-670. PMID: 27451287, PMCID: PMC5280016, DOI: 10.1681/asn.2016010091.Peer-Reviewed Original ResearchConceptsYKL-40 concentrationsDonor kidneysYKL-40Renal recoveryDeceased donor kidney transplantationRisk of DGFAcute tubular necrosisDeceased kidney donorsDonor kidney transplantationProspective cohort studyPoor transplant outcomesDeceased donor kidneysOrgan procurement organizationsDonor biomarkersGraft functionKidney transplantationCohort studyGraft failureTransplant outcomesTubular injuryTubular necrosisRecipient outcomesKidney donorsProcurement biopsiesPrognostic biomarker