2018
VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine
Jiang C, Lin WJ, Labonté B, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR. VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine. Neuropsychopharmacology 2018, 44: 971-981. PMID: 30504797, PMCID: PMC6462025, DOI: 10.1038/s41386-018-0277-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsBehavior, AnimalBrain-Derived Neurotrophic FactorDepressionDepressive Disorder, MajorDisease Models, AnimalDisease SusceptibilityFemaleHumansKetamineMaleMiceMice, 129 StrainMice, Inbred C57BLMice, TransgenicNerve Growth FactorsNeuropeptidesPeptidesPrefrontal CortexStress, PsychologicalConceptsChronic restraint stressMajor depressive disorderAntidepressant efficacyAntidepressant responseVentromedial prefrontal cortexPrefrontal cortexAntidepressant drug treatmentKetamine's antidepressant efficacyAntidepressant-like effectsDepression-related behaviorsBrodmann area 25Neuropeptide precursor VGFChannel-mediated Ca2Underlying molecular pathwaysTLQP-62Vgf knockdownVGF levelsBDNF expressionMDD patientsRestraint stressDepressive disorderFunctional deficitsDrug treatmentBehavioral deficitsNucleus accumbens
2013
The role of neurotrophins in major depressive disorder
Jiang C, Salton S. The role of neurotrophins in major depressive disorder. Translational Neuroscience 2013, 4: 46-58. PMID: 23691270, PMCID: PMC3656715, DOI: 10.2478/s13380-013-0103-8.Peer-Reviewed Original ResearchBrain-derived neurotrophic factorDepressive behaviorRole of neurotrophinsMajor depressive disorderTransgenic mouse modelStability of synapsesComplex brain circuitryAntidepressant effectsDendritic lengthSpine densityNeurotrophic factorDepressive disorderNeuronal cytoarchitectureNucleus accumbensMouse modelAnalyses of knockoutBrain circuitryPrefrontal cortexNeurotrophinsGrowth factorSingle nucleotide polymorphismsCritical modulatorHuman genetic studiesSubtle alterationsNucleotide polymorphisms