Inhibition of endocytosis of porcine reproductive and respiratory syndrome virus by rottlerin and its potential prophylactic administration in piglets
Kang Y, Oh C, Ahn S, Choi J, Choi H, Lee S, Choi I, Song C, Lee J, Park S. Inhibition of endocytosis of porcine reproductive and respiratory syndrome virus by rottlerin and its potential prophylactic administration in piglets. Antiviral Research 2021, 195: 105191. PMID: 34678331, DOI: 10.1016/j.antiviral.2021.105191.Peer-Reviewed Original ResearchConceptsAnti-PRRSV effectPRRSV infectionBlood viral loadRespiratory syndrome virusInterstitial pneumoniaProphylactic administrationClinical scoresViral loadProphylactic treatmentAntiviral effectAntiviral agentsPRRSV internalizationViral replicationUntreated pigsProtein kinase CTreatmentΔ phosphorylationEntry pathwayInfectionInhibition of endocytosisRottlerinKinase CLimited studiesVivoPigs