2022
Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death
Wisnewski AV, Cooney R, Hodgson M, Giese K, Liu J, Redlich CA. Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death. American Journal Of Industrial Medicine 2022, 65: 166-172. PMID: 35028957, PMCID: PMC8846433, DOI: 10.1002/ajim.23323.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAsthma, OccupationalHumansImmunoglobulin EImmunoglobulin GIsocyanatesOccupational ExposureConceptsCause of deathMedical recordsDiisocyanate asthmaSevere asthmaSerum IgEParaffin-embedded lung tissue sectionsWorkers' medical recordsSmooth muscle hypertrophyTotal serum IgEHallmark of asthmaSevere asthma attacksBasement membrane thickeningLung tissue sectionsPost-mortem findingsEnzyme-linked immunosorbent assayPotential chemical exposuresInflamed airwaysMucus pluggingOccupational asthmaPulmonary embolismTotal IgEAsthma deathsAsthma attacksLung pathologyAutopsy findings
2017
Medical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States
Cassidy LD, Doney B, Wang ML, Kurth L, Conner PR, Collins JJ, Carson M, Molenaar D, Redlich CA, Storey E. Medical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States. Journal Of Occupational And Environmental Medicine 2017, 59: s13-s21. PMID: 29200134, PMCID: PMC5728423, DOI: 10.1097/jom.0000000000001197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAsthma, OccupationalChemical IndustryEnvironmental MonitoringFemaleForced Expiratory VolumeHumansMaleMiddle AgedOccupational ExposurePopulation SurveillanceProgram EvaluationReferral and ConsultationSpirometrySurveys and QuestionnairesSymptom AssessmentToluene 2,4-DiisocyanateUnited StatesYoung AdultConceptsLung function criteriaOccupational health programWeb-based data collection systemTDI workersOccupational asthmaPossible asthmaStudy protocolHealth outcomesMultidisciplinary teamHealth programsMedical monitoringAsthmaFurther evaluationEligible workersFurther assessmentResearch protocolPotential casesSubsequent evaluationProduction workersSymptomsToluene diisocyanateWorkersEvaluationIncidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry
Collins JJ, Anteau S, Conner PR, Cassidy LD, Doney B, Wang ML, Kurth L, Carson M, Molenaar D, Redlich CA, Storey E. Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry. Journal Of Occupational And Environmental Medicine 2017, 59: s22-s27. PMID: 29200135, PMCID: PMC5763544, DOI: 10.1097/jom.0000000000000890.Peer-Reviewed Original ResearchRecommendations for a Clinical Decision Support System for Work-Related Asthma in Primary Care Settings
Harber P, Redlich CA, Hines S, Filios MS, Storey E. Recommendations for a Clinical Decision Support System for Work-Related Asthma in Primary Care Settings. Journal Of Occupational And Environmental Medicine 2017, 59: e231-e235. PMID: 29023337, PMCID: PMC6282164, DOI: 10.1097/jom.0000000000001182.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsWork-related asthmaElectronic health recordsPossible work-related asthmaPrimary care health care providersMortality of asthmaPrimary care settingSpecific clinical conditionsAmerican Thoracic SocietyHealth care providersClinical decision support systemAsthma symptomsAsthma diagnosisThoracic SocietyPossible referralCare settingsClinical conditionsCare providersAsthmaAvailable guidelinesFurther evaluationHealth recordsClinical decision support approachEHR systemsPositive responseSpecific recommendations
2014
Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up
Gui W, Wisnewski AV, Neamtiu I, Gurzau E, Sparer JA, Stowe MH, Liu J, Slade MD, Rusu OA, Redlich CA. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up. American Journal Of Industrial Medicine 2014, 57: 1207-1215. PMID: 25266741, PMCID: PMC4198484, DOI: 10.1002/ajim.22385.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAirway ObstructionAsthma, OccupationalFemaleFollow-Up StudiesForced Expiratory VolumeHumansImmunoglobulin EImmunoglobulin GLost to Follow-UpMaleMiddle AgedOccupational ExposurePolyurethanesPrevalenceProspective StudiesTime FactorsToluene 2,4-DiisocyanateVital CapacityYoung AdultConceptsAsthma symptomsIsocyanate asthmaInception cohort studyHealth effectsCurrent asthma symptomsTDI levelsFirst yearFurther longitudinal evaluationAirflow obstructionCohort studyInception cohortOccupational asthmaTDI exposureRespiratory healthSkin exposureLongitudinal evaluationAsthmaOne-yearPersonal samplingSymptomsRiskExposureFindingsFEV1Spirometry
2013
Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure
Wisnewski AV, Liu J, Redlich CA. Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure. Chemico-Biological Interactions 2013, 205: 38-45. PMID: 23791970, PMCID: PMC3767171, DOI: 10.1016/j.cbi.2013.06.005.Peer-Reviewed Original Research
2012
Transferability of Aliphatic Isocyanates from Recently Applied Paints to the Skin of Auto Body Shop Workers
De Vries TT, Bello D, Stowe MH, Harari H, Slade MD, Redlich CA. Transferability of Aliphatic Isocyanates from Recently Applied Paints to the Skin of Auto Body Shop Workers. Journal Of Occupational And Environmental Hygiene 2012, 9: 699-711. PMID: 23067057, DOI: 10.1080/15459624.2012.728893.Peer-Reviewed Original ResearchMeSH KeywordsAsthma, OccupationalEnvironmental PollutantsHumansIsocyanatesMotor VehiclesOccupational ExposurePaintSkinConceptsSkin exposureSkin samplesAuto body shop workersOccupational asthmaIsocyanate asthmaCommon causeSkin wipesGreater riskSkin contactPotent sensitizerInitial sampling timeShop workersPositive samplesAsthmaAuto body shopsHigh-performance liquid chromatographyExposureCross-linking chemicalsRiskGeometric meanLiquid chromatographyPrimary prevention: exposure reduction, skin exposure and respiratory protection
Heederik D, Henneberger PK, Redlich CA. Primary prevention: exposure reduction, skin exposure and respiratory protection. European Respiratory Review 2012, 21: 112-124. PMID: 22654083, PMCID: PMC9487304, DOI: 10.1183/09059180.00005111.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAsthma, OccupationalGloves, ProtectiveHumansOccupational ExposurePrimary PreventionRespiratory Protective DevicesTreatment OutcomeConceptsOccupational asthmaPrimary preventionSkin exposureLiterature searchExposure reductionSystematic literature searchNatural rubber latex glovesEffectiveness of respiratorsOccupational exposurePrimary preventive approachAsthmaExposure eliminationWork exposureWorkplace exposuresMedical literatureLatex glovesFuture interventionsPreventive approachPreventionRespiratory protectionExposureInterventionWeak evidenceEvidenceBest option