2022
Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death
Wisnewski AV, Cooney R, Hodgson M, Giese K, Liu J, Redlich CA. Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death. American Journal Of Industrial Medicine 2022, 65: 166-172. PMID: 35028957, PMCID: PMC8846433, DOI: 10.1002/ajim.23323.Peer-Reviewed Case Reports and Technical NotesConceptsCause of deathMedical recordsDiisocyanate asthmaSevere asthmaSerum IgEParaffin-embedded lung tissue sectionsWorkers' medical recordsSmooth muscle hypertrophyTotal serum IgEHallmark of asthmaSevere asthma attacksBasement membrane thickeningLung tissue sectionsPost-mortem findingsEnzyme-linked immunosorbent assayPotential chemical exposuresInflamed airwaysMucus pluggingOccupational asthmaPulmonary embolismTotal IgEAsthma deathsAsthma attacksLung pathologyAutopsy findings
2021
Polyisocyanates and Their Prepolymers
Jolly A, Maestrelli P, Redlich C, Malo J, Bernstein D. Polyisocyanates and Their Prepolymers. 2021, 179-194. DOI: 10.1201/9781003000624-14.ChaptersOccupational asthmaHuman leukocyte antigenAirway inflammationDiisocyanate-induced occupational asthmaSensitizer-induced occupational asthmaWeight agentsOnset of asthmaOnset of symptomsLong-term outcomesMedical surveillance programNon-HLA genesReduction of exposureAverage exposure levelsAirway hyperresponsivenessSevere asthmaAsthmatic symptomsClinical presentationNeutrophilic infiltrateLeukocyte antigenClinical assessmentDifferent exposure metricsIrritant concentrationsHigh riskMechanism of sensitizationIsocyanate exposure