2005
Evidence for Excess Colorectal Cancer Incidence among Asbestos-exposed Men in the Beta-Carotene and Retinol Efficacy Trial
Aliyu OA, Cullen MR, Barnett MJ, Balmes JR, Cartmel B, Redlich CA, Brodkin CA, Barnhart S, Rosenstock L, Israel L, Goodman GE, Thornquist MD, Omenn GS. Evidence for Excess Colorectal Cancer Incidence among Asbestos-exposed Men in the Beta-Carotene and Retinol Efficacy Trial. American Journal Of Epidemiology 2005, 162: 868-878. PMID: 16177148, DOI: 10.1093/aje/kwi285.Peer-Reviewed Original ResearchConceptsRetinol Efficacy TrialColorectal cancer riskHeavy smokersColorectal cancerAsbestos exposureRelative riskEfficacy trialsCancer riskBeta caroteneAsbestos-exposed menColorectal cancer incidenceMale heavy smokersProportional hazards modelDose-response trendIntervention armPleural plaquesLung cancerRadiographic changesCancer incidencePulmonary asbestosisHazards modelCancerUS studiesSmokersRiskChanges in cholesterol and triglyceride concentrations in the Vanguard population of the Carotene and Retinol Efficacy Trial (CARET)
Cartmel B, Dziura J, Cullen MR, Vegso S, Omenn GS, Goodman GE, Redlich CA. Changes in cholesterol and triglyceride concentrations in the Vanguard population of the Carotene and Retinol Efficacy Trial (CARET). European Journal Of Clinical Nutrition 2005, 59: 1173-1180. PMID: 16015255, DOI: 10.1038/sj.ejcn.1602229.Peer-Reviewed Original ResearchConceptsRetinol Efficacy TrialPlacebo armSerum triglyceridesTriglyceride concentrationsEfficacy trialsVitamin ASerum cholesterol concentrationActive intervention armsActive intervention groupNational Cancer InstituteCardiovascular deathPlacebo groupCardiovascular mortalitySerum lipidsTotal cholesterolIntervention armSerum cholesterolVanguard StudyLung cancerIntervention groupCardiovascular diseaseCancer InstituteCholesterol concentrationsActive armBeta carotenePredictors of Lung Cancer among Asbestos-exposed Men in the β-Carotene and Retinol Efficacy Trial
Cullen MR, Barnett MJ, Balmes JR, Cartmel B, Redlich CA, Brodkin CA, Barnhart S, Rosenstock L, Goodman GE, Hammar SP, Thornquist MD, Omenn GS. Predictors of Lung Cancer among Asbestos-exposed Men in the β-Carotene and Retinol Efficacy Trial. American Journal Of Epidemiology 2005, 161: 260-270. PMID: 15671258, DOI: 10.1093/aje/kwi034.Peer-Reviewed Original ResearchConceptsRetinol Efficacy TrialLung cancerEfficacy trialsAsbestos-exposed menStudy intervention armSubsequent lung cancerStrong independent predictorLung cancer incidenceLung cancer riskNormal lung parenchymaProportional hazards modelBaseline flow ratesRadiographic asbestosisIndependent predictorsStudy armsIntervention armVitamin supplementationPleural plaquesBaseline radiographsResidual confoundingCancer incidenceChest radiographsLung parenchymaLung carcinogenCancer risk
1999
Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET)
Redlich C, Chung J, Cullen M, Blaner W, Van Bennekum A, Berglund L. Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET). Atherosclerosis 1999, 145: 425-432. PMID: 10488974, DOI: 10.1016/s0021-9150(99)00266-x.Peer-Reviewed Original ResearchConceptsSerum triglyceride levelsHigh-density lipoproteinActive treatment groupLDL cholesterol levelsTriglyceride levelsCancer chemoprevention trialsCholesterol levelsSmall nonsignificant increaseCARET participantsCardiovascular mortalityTreatment groupsNonsignificant increaseLow-density lipoprotein cholesterol levelsLung cancer chemoprevention trialsRetinol Efficacy TrialActive treatment armsLipoprotein cholesterol levelsLung cancer mortalityLong-term supplementationActive intervention groupTreatment-induced changesSerum lipidsChemoprevention trialsHDL cholesterolActive treatmentErratum to “Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy trial (CARET)” [Atherosclerosis 143 (1999) 427–434]
Redlich C, Chung J, Cullen M, Blaner W, Van Bennekum A, Berglund L. Erratum to “Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy trial (CARET)” [Atherosclerosis 143 (1999) 427–434]. Atherosclerosis 1999, 145: 423. DOI: 10.1016/s0021-9150(99)00270-1.Peer-Reviewed Original ResearchEffect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET)
Redlich C, Chung J, Cullen M, Blaner W, Van Bennekum A, Berglund L. Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET). Atherosclerosis 1999, 143: 427-434. PMID: 10217373, DOI: 10.1016/s0021-9150(98)00303-7.Peer-Reviewed Original ResearchConceptsSerum triglyceride levelsHigh-density lipoproteinActive treatment groupLDL cholesterol levelsTriglyceride levelsCancer chemoprevention trialsCholesterol levelsSmall nonsignificant increaseCARET participantsCardiovascular mortalityTreatment groupsNonsignificant increaseLow-density lipoprotein cholesterol levelsLung cancer chemoprevention trialsRetinol Efficacy TrialActive treatment armsLipoprotein cholesterol levelsLung cancer mortalityLong-term supplementationActive intervention groupTreatment-induced changesSerum lipidsChemoprevention trialsHDL cholesterolActive treatment
1998
Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels.
Redlich CA, Blaner WS, Van Bennekum AM, Chung JS, Clever SL, Holm CT, Cullen MR. Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels. Cancer Epidemiology Biomarkers & Prevention 1998, 7: 211-4. PMID: 9521435.Peer-Reviewed Original ResearchConceptsActive armRetinol levelsLung tissueExcess lung cancer mortalityLung cancer chemoprevention trialsLung retinol levelsRetinol Efficacy TrialLung tissue levelsLung cancer mortalityCancer chemoprevention trialsEffect of supplementationLung retinolChemoprevention trialsCancer mortalitySurgical controlEfficacy trialsCell levelVitamin ARetinyl palmitateSame interventionTissue levelsBiomarker studiesSupplementationInterventionTrials