123I-5-IA-85380 SPECT Imaging of Nicotinic Acetylcholine Receptor Availability in Nonsmokers: Effects of Sex and Menstrual Phase
Cosgrove KP, Mitsis EM, Bois F, Frohlich E, Tamagnan GD, Krantzler E, Perry E, Maciejewski PK, Epperson CN, Allen S, O'Malley S, Mazure CM, Seibyl JP, van Dyck CH, Staley JK. 123I-5-IA-85380 SPECT Imaging of Nicotinic Acetylcholine Receptor Availability in Nonsmokers: Effects of Sex and Menstrual Phase. Journal Of Nuclear Medicine 2007, 48: 1633-1640. PMID: 17873128, DOI: 10.2967/jnumed.107.042317.Peer-Reviewed Original ResearchConceptsRegional brain activityMenstrual cycleNAChR availabilityWomen nonsmokersMenstrual phaseRadiotracer metabolismNicotinic acetylcholine receptor systemSex differencesBrain activityEffects of sexNicotinic acetylcholine receptor availabilitySmoking cessation treatmentMid-luteal phaseAcetylcholine receptor systemPlasma protein bindingTobacco smokingCessation treatmentHealthy menRegional brainHormone levelsPlasma measuresTreatment responseOutcome measuresSPECT scansNonsmokersEvolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry
Cosgrove KP, Mazure CM, Staley JK. Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry. Biological Psychiatry 2007, 62: 847-855. PMID: 17544382, PMCID: PMC2711771, DOI: 10.1016/j.biopsych.2007.03.001.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingFunctional magnetic resonance imagingPositron emission tomographyBrain structuresPsychiatric disordersHealthy individualsFemale brainResonance imagingSex differencesGlobal cerebral blood flowRegional volume differencesCerebral blood flowDevastating brain disorderStructural magnetic resonance imagingSex-specific treatmentsGamma-aminobutyric acidEnglish-language literatureSingle photon emissionEpidemiologic evidencePathophysiological mechanismsHealthy menHigh percentageMEDLINE searchSex-specific differencesBlood flow