2022
Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report
Acquarulo B, Tandon P, Macica C. Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report. Journal Of Medical Case Reports 2022, 16: 253. PMID: 35765109, PMCID: PMC9241182, DOI: 10.1186/s13256-022-03479-4.Peer-Reviewed Original ResearchMeSH KeywordsBacopaCholinergic AgentsCytochrome P-450 Enzyme SystemFemaleHumansMiddle AgedQuinuclidinesSjogren's SyndromeThiophenesConceptsSjögren's syndromePossible drug-herb interactionsPrimary care officesDrug-herb interactionsST-T changesCevimeline hydrochlorideClinical improvementUndesirable side effectsUrinary retentionCase presentationACare officesCase reportCholinergic toxicityCaucasian femaleHerbal supplementsSide effectsClinical relevanceDrug responsivenessCommon genetic variantsSyndromeDrugsPrevious nightCytochrome P450Genetic variantsSupplementation interaction
1993
Characterization of cytochrome P-450-dependent arachidonic acid metabolism in rabbit intestine
Macica C, Balazy M, Falck J, Mioskowski C, Carroll M. Characterization of cytochrome P-450-dependent arachidonic acid metabolism in rabbit intestine. American Journal Of Physiology 1993, 265: g735-g741. PMID: 8238357, DOI: 10.1152/ajpgi.1993.265.4.g735.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachidonic AcidChromatography, LiquidCytochrome P-450 Enzyme SystemGas Chromatography-Mass SpectrometryHydroxyeicosatetraenoic AcidsIleumIntestinal MucosaMaleRabbitsTissue DistributionConceptsEpithelial ion transportAA metabolitesNew Zealand white male rabbitsRegional blood flowArachidonic acid metabolismWhite male rabbitsDuodenal microsomesIleal microsomesMesenteric bedIntestinal functionArachidonate metabolismBW 755CBlood flowHigh-pressure liquid chromatographyEnzyme inhibitorsMale rabbitsAA metabolismIntestinal tractSKF-525ALipoxygenase inhibitorsRabbit intestineMicrosomal activityPresence of NADPHAbsence of NADPHAcid metabolism