2008
Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone–related protein in mice
Chen X, Macica CM, Nasiri A, Broadus AE. Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone–related protein in mice. Arthritis & Rheumatism 2008, 58: 3788-3797. PMID: 19035497, PMCID: PMC2599803, DOI: 10.1002/art.23985.Peer-Reviewed Original ResearchConceptsPTHrP expressionParathyroid hormone-related proteinArticular cartilagePTHrP-knockout micePathogenesis of arthritisWeight-bearing jointsHormone-related proteinChondrocyte proliferationIndian hedgehogGrowth plate structureCell of originArticular chondrocytesEpiphyseal growth zoneSecondary ossification centerArticular chondrocyte differentiationArticular chondrocyte proliferationAdult miceAxis participatesKnockin miceMicePTHrPProtein axisOssification centersIhhCartilage
2006
Induction of parathyroid hormone‐related peptide following peripheral nerve injury: Role as a modulator of Schwann cell phenotype
Macica CM, Liang G, Lankford KL, Broadus AE. Induction of parathyroid hormone‐related peptide following peripheral nerve injury: Role as a modulator of Schwann cell phenotype. Glia 2006, 53: 637-648. PMID: 16470617, DOI: 10.1002/glia.20319.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell DifferentiationCell ProliferationCells, CulturedCyclic AMP Response Element-Binding ProteinDisease Models, AnimalGanglia, SpinalGrowth ConesLigationMiceNerve RegenerationNeurons, AfferentParathyroid Hormone-Related ProteinPeripheral Nerve InjuriesPeripheral NervesRatsRats, Sprague-DawleyReceptor, Parathyroid Hormone, Type 1RNA, MessengerSchwann CellsSciatic NerveSciatic NeuropathyUp-RegulationConceptsSciatic nerve injury modelNerve injury modelPeripheral nerve injuryRole of PTHrPHormone-related peptideSchwann cellsSciatic nerveNerve injuryInjury modelNerve regenerationNervous systemParathyroid hormone-related peptideInjured sciatic nerveDedifferentiated Schwann cellsSchwann cell phenotypeRat nervous systemPeripheral nervous systemPTHrP receptor mRNASuccessful nerve regenerationType 1 collagen matrixSchwann cell culturesSympathetic gangliaPTHrP functionsPTHrP mRNAReceptor mRNA
2005
Stretch‐Induced PTH‐Related Protein Gene Expression in Osteoblasts*
Chen X, Macica CM, Ng KW, Broadus AE. Stretch‐Induced PTH‐Related Protein Gene Expression in Osteoblasts*. Journal Of Bone And Mineral Research 2005, 20: 1454-1461. PMID: 16007342, DOI: 10.1359/jbmr.2005.20.8.1454.Peer-Reviewed Original ResearchConceptsAnabolic effectsStretch-activated potassium channelsCandidate mediatorsCyclical stretchPotassium channelsL-type calcium channelsN-terminal PTHPTHrP mRNA expressionStretch-activated cation channelsSmooth muscle cellsOsteoblast-like cellsUMR 201PTHrP gene expressionHypotonic solutionEndogenous mediatorsPTHrP mRNAIntracellular acidosisExtracellular calciumCalcium channelsFlexercell apparatusPTHrPRNase protection assaysMRNA expressionMuscle cellsSkeletal mass