2024
Lisdexamfetamine maintenance treatment for binge-eating disorder following successful treatments: randomized double-blind placebo-controlled trial
Grilo C, Ivezaj V, Yurkow S, Tek C, Wiedemann A, Gueorguieva R. Lisdexamfetamine maintenance treatment for binge-eating disorder following successful treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2024, 54: 3334-3344. PMID: 39258475, PMCID: PMC11496227, DOI: 10.1017/s003329172400148x.Peer-Reviewed Original ResearchEating-disorder psychopathologyBinge-eating disorderMaintenance treatmentAcute treatmentBinge-eating remission ratesCognitive-behavioral therapyEfficacy of lisdexamfetamineSignificant weight gainDouble-blind placebo-controlled trialAcute respondersLisdexamfetamine treatmentPsychopathological outcomesPosttreatment assessmentLisdexamfetaminePlacebo-controlled trialRandomized double-blind placebo-controlled trialSingle-site trialAssociated with significant weight lossPsychopathologyBinge-eatingRemission rateWeight lossPlaceboRelapse rateControl researchExploring Dietary Restraint as a Mediator of Behavioral and Cognitive‐Behavioral Treatments on Outcomes for Patients With Binge‐Eating Disorder With Obesity
Grilo C, Pittman B. Exploring Dietary Restraint as a Mediator of Behavioral and Cognitive‐Behavioral Treatments on Outcomes for Patients With Binge‐Eating Disorder With Obesity. International Journal Of Eating Disorders 2024 PMID: 39247962, DOI: 10.1002/eat.24288.Peer-Reviewed Original ResearchCognitive-behavioral therapyBehavioral weight lossBinge-eating disorderBinge eatingWeight loss outcomesCognitive-behavioral treatmentMediation of behaviorEDE-Q restraintPost-treatmentCognitive-behavioralRestraint ScaleDietary restraintBingeMediation effectEatingEffects of treatmentTreatment effectsDisordersRandomized controlled trialsWeight lossMonths of treatmentHypothesis-testingSecondary analysisRestraintBinge-eatingTreatment of Eating Disorders: Current Status, Challenges, and Future Directions
Grilo C. Treatment of Eating Disorders: Current Status, Challenges, and Future Directions. Annual Review Of Clinical Psychology 2024, 20: 97-123. PMID: 38211625, DOI: 10.1146/annurev-clinpsy-080822-043256.Peer-Reviewed Original ResearchAnorexia nervosaBinge-eating disorderBulimia nervosaEating disordersAdaptive treatment designsPsychological treatmentTreatment researchNervosaTreatment designDisordersBulimiaPharmacological optionsAnorexiaEnhanced outcomesExpected final online publication dateFirst-line approachOnline publication dateMedicationFirst-lineClinical guidanceAnnual ReviewAlternative treatmentRevised estimatesPatientsTreatmentNeural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge‐Eating Disorder
Chao A, Agarwal K, Zhou Y, Grilo C, Gur R, Joseph P, Shinohara R, Richmond T, Wadden T. Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge‐Eating Disorder. International Journal Of Eating Disorders 2024, 57: 1911-1923. PMID: 38953334, PMCID: PMC11483217, DOI: 10.1002/eat.24244.Peer-Reviewed Original ResearchCognitive behavioral therapyFunctional magnetic resonance imagingBlood oxygen level-dependentWait-list controlBinge-eating disorderBehavioral therapyFunctional magnetic resonance imaging sessionNeutral-relaxing cuesReward-based eating driveReward-related regionsReducing binge eatingMeasured BOLD responsesReward regionsBinge eatingBinge-eating episodesFood cuesEating drivePersonalized scriptsBOLD responseRandomized controlled trialsNeural responsesFood-stimuliBinge-eatingCuesMagnetic resonance imagingOvervaluation of shape/weight at posttreatment predicts relapse at 12‐month follow‐up after successful behaviorally‐based treatment of binge‐eating disorder
Grilo C, Ivezaj V, Gueorguieva R. Overvaluation of shape/weight at posttreatment predicts relapse at 12‐month follow‐up after successful behaviorally‐based treatment of binge‐eating disorder. International Journal Of Eating Disorders 2024, 57: 1268-1273. PMID: 38321617, PMCID: PMC11093697, DOI: 10.1002/eat.24141.Peer-Reviewed Original ResearchOvervaluation of shape/weightEating-disorder psychopathologyBinge-eating disorderEating Disorder Examination interviewBeck Depression InventoryWeight loss treatmentClinical overvaluationBinge-eating frequencyDiagnostic specifierBinge eatingNon-abstinenceExamination interviewDepression InventoryShape/weightDepression scoresFollow-upPsychopathologyAbstinenceBingeDepressionClinical implicationsDepression 1PosttreatmentDisordersOvervaluationReliability of the original and brief versions of the Eating Disorder Examination in binge‐eating disorder
Lydecker J, Ivezaj V, Wiedemann A, Kerrigan S, Grilo C. Reliability of the original and brief versions of the Eating Disorder Examination in binge‐eating disorder. Obesity 2024, 32: 702-709. PMID: 38311600, PMCID: PMC10965370, DOI: 10.1002/oby.23993.Peer-Reviewed Original ResearchEating Disorder ExaminationEating Disorder Examination interviewEating-disorder psychopathologyBinge-eating disorderInternal consistencyDoctoral-levelIndicators of loss of controlInterrater reliabilityLoss of controlBinge eatingBinge-eating episodesPsychological treatmentPsychometric propertiesPsychometric studyTests of reliabilityBehavioral indicatorsAssessed adultsClinical researchPsychopathologyEatingRatersDisordersAudio-recordedAdultsPatient groupThe children of parents who receive treatment for binge‐eating disorder experience improvements in disordered eating
Lydecker J, Ozbardakci E, Grilo C. The children of parents who receive treatment for binge‐eating disorder experience improvements in disordered eating. International Journal Of Eating Disorders 2024, 57: 745-751. PMID: 38308384, PMCID: PMC10947894, DOI: 10.1002/eat.24153.Peer-Reviewed Original ResearchBinge-eating disorderBinge eatingDisordered eating behaviorsEating behaviorsSecretive eatingParent changesDisordered eatingAssociated with disordered eating behaviorsEating-disorder psychopathologyEnd-of-treatment assessmentParental eating disordersAssociated with changesChildren of parentsCross-sectional workChild disordered eating behaviorsBinge-eating frequencyEating disordersSchool-aged childrenParental treatmentUntreated family membersParent medicationLongitudinal researchBingeBaseline assessmentEating
2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionImprovements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity
Yurkow S, Ivezaj V, Grilo C. Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity. International Journal Of Eating Disorders 2023, 56: 2074-2083. PMID: 37530200, PMCID: PMC10834830, DOI: 10.1002/eat.24035.Peer-Reviewed Original ResearchConceptsCardiovascular disease risk factorsModest weight lossDisease risk factorsBinge-eating disorderPlasma glucoseRisk factorsWeight lossLifestyle changesBehavioral lifestyle changesCardiovascular disease riskWeight loss treatmentSignificant improvementRelated lifestyle changesTotal cholesterolPotential health benefitsHeart ratePatientsObesityDisease riskHbA1cHealth benefitsDisordersTriglyceridesTreatmentPosttreatmentNaltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlaceboCognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapyLoss of control in binge‐eating disorder: Fear and resignation
Perelman H, Gilbert K, Grilo C, Lydecker J. Loss of control in binge‐eating disorder: Fear and resignation. International Journal Of Eating Disorders 2023, 56: 1199-1206. PMID: 36920120, PMCID: PMC10247475, DOI: 10.1002/eat.23929.Peer-Reviewed Original ResearchConceptsBinge-eating disorderCognitive-affective experiencesLoss of controlModerate treatment outcomeBinge-eating episodesEating-disorder psychopathologyTreatment-seeking patientsFuture researchAbsence of fearGreater distressPsychopathologyFearSevere psychopathologyResearch cliniciansSemistructured interviewsTreatment formulationPast monthDisordersResignationTreatment outcomesExperienceBlack individualsEmotionsTreatment planningIndividuals
2022
Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy
Forrest L, Franko D, Thompson‐Brenner H, Grilo C. Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy. International Journal Of Eating Disorders 2022, 56: 944-955. PMID: 36565241, PMCID: PMC10159900, DOI: 10.1002/eat.23883.Peer-Reviewed Original ResearchConceptsBinge-eating disorderCognitive behavioral therapyEvidence-based treatmentsInterpersonal psychotherapyIntervention targetsBinge-eating disorder symptomsBehavioral therapyIndicator of remissionShape concernsRefinement of treatmentClinical utilityFrequent associationClinical implicationsSymptomsSymptom interactionsTherapyInterpersonal therapyWeight concernsDisorder symptomsSymptom relationshipsDisordersPatientsTreatmentSizeable minorityNetwork of symptoms
2020
170 Efficacy and Safety of Dasotraline in Adults with Binge-Eating Disorder: A Randomized, Double-blind, Fixed-dose Trial
Tsai J, Navia B, McElroy S, Hudson J, Grilo C, Goldman R, Deng L, Kent J, Loebel A. 170 Efficacy and Safety of Dasotraline in Adults with Binge-Eating Disorder: A Randomized, Double-blind, Fixed-dose Trial. CNS Spectrums 2020, 25: 308-309. DOI: 10.1017/s1092852920000863.Peer-Reviewed Original ResearchBinge-eating disorderEfficacy endpointWeek 12Dopamine/norepinephrine reuptake inhibitorFlexible-dose studySafety of dasotralineDouble-blind treatmentFixed-dose studyPrimary efficacy endpointProportion of patientsSecondary efficacy endpointsClinical Global ImpressionNorepinephrine reuptake inhibitorsWeeks of treatmentTreatment of patientsCompulsive Scale ModifiedBinge-eating episodesDSM-5 criteriaYale-Brown ObsessiveITT populationReuptake inhibitorsGlobal ImpressionDose studySignificant efficacySeverity Scale
2018
Loss-of-control eating after bariatric/sleeve gastrectomy surgery: Similar to binge-eating disorder despite differences in quantities
Ivezaj V, Barnes RD, Cooper Z, Grilo CM. Loss-of-control eating after bariatric/sleeve gastrectomy surgery: Similar to binge-eating disorder despite differences in quantities. General Hospital Psychiatry 2018, 54: 25-30. PMID: 30056316, PMCID: PMC6245943, DOI: 10.1016/j.genhosppsych.2018.07.002.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryBinge-eating disorderGastrectomy surgeryBinge Eating DisorderClinical featuresPatient groupControl eatingOW/OBOverweight/obesityBody mass indexRelevant patient groupsMass indexDepressive symptomsSurgeryPast monthBED groupWeight concernsWeekly lossDisordersCareful assessmentObesityOnly groupQuantity of foodComparable levelsEatingEarly weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change
Barnes RD, Ivezaj V, Pittman BP, Grilo CM. Early weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change. International Journal Of Eating Disorders 2018, 51: 558-564. PMID: 29637592, PMCID: PMC6002900, DOI: 10.1002/eat.22860.Peer-Reviewed Original ResearchConceptsEarly weight lossWeight loss treatmentBinge-eating disorderLoss treatmentWeight lossBed statusWeight loss treatment outcomesOverweight/obesityWeight loss trialAverage weight lossWeight-related variablesPrognostic significancePrimary careTreatment outcomesTreatment responseLoss trialWeight trajectoriesTreatment studiesDisorder statusWeight changeOutcomesTreatmentIndividual responsesStatusPositive outcomesComparing men and women with binge‐eating disorder and co‐morbid obesity
Lydecker JA, Grilo CM. Comparing men and women with binge‐eating disorder and co‐morbid obesity. International Journal Of Eating Disorders 2018, 51: 411-417. PMID: 29493793, PMCID: PMC5980708, DOI: 10.1002/eat.22847.Peer-Reviewed Original ResearchConceptsBody mass indexBinge-eating disorderEating-disorder psychopathologyBinge-eating episodesBinge-eating behaviorClinical presentationResearch cliniciansHigher body mass indexCo-morbid obesityDSM-IV disordersStructured Clinical InterviewEating Disorder Examination interviewAge of onsetBinge-eating frequencyRace/ethnicityMass indexBED diagnosisClinical InterviewYounger ageObesityExamination interviewWomenMenAgeDisorders
2017
Examining motivational interviewing plus nutrition psychoeducation for weight loss in primary care
Barnes RD, Ivezaj V, Martino S, Pittman BP, Paris M, Grilo CM. Examining motivational interviewing plus nutrition psychoeducation for weight loss in primary care. Journal Of Psychosomatic Research 2017, 104: 101-107. PMID: 29275778, PMCID: PMC5774024, DOI: 10.1016/j.jpsychores.2017.11.013.Peer-Reviewed Original ResearchConceptsBinge-eating disorderNutrition psychoeducationMotivational interviewingUsual careAttention control conditionWeight lossPrimary careBasic nutrition informationOverweight/obesityModerate weight lossPsychological improvementPsychoeducationMore weight lossMixed model analysisMixed-model analysisPrognostic significanceTreatment completionScalable combinationCurrent studyPercentage weight lossParticipantsBed statusNutrition informationCareGreater improvementForm and Formulation: Examining the Distinctiveness of Body Image Constructs in Treatment-Seeking Patients With Binge-Eating Disorder
Lydecker JA, White MA, Grilo CM. Form and Formulation: Examining the Distinctiveness of Body Image Constructs in Treatment-Seeking Patients With Binge-Eating Disorder. Journal Of Consulting And Clinical Psychology 2017, 85: 1095-1103. PMID: 29083224, PMCID: PMC5679782, DOI: 10.1037/ccp0000258.Peer-Reviewed Original ResearchConceptsBody image variablesBody image disturbanceBody image constructsBinge-eating disorderImage constructImage variablesWeight/shape overvaluationBinge-eating frequencyInvestigator-based interviewBiopsychosocial featuresEating-disorder psychopathologyTreatment-seeking patientsShape preoccupationShape dissatisfactionShape overvaluationShape concernsCore aspectsCurrent studyTreatment formulationConstructsImportant distinctionDifferent aspectsOvervaluationPreoccupationDisordersBack to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up
Barnes RD, Ivezaj V, Martino S, Pittman BP, Grilo CM. Back to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up. Obesity 2017, 25: 2074-2078. PMID: 29086484, PMCID: PMC5705439, DOI: 10.1002/oby.21972.Peer-Reviewed Original ResearchConceptsWeight loss interventionPrimary careBinge-eating disorderWeight lossNutrition psychoeducationLoss interventionSecondary end point analysisWeight loss 12 monthsAttention-controlled comparisonMotivational interviewingMIC patientsEnd-point analysisTreatment conclusionOne-yearBed statusSmall effect sizesCareMonthsPatientsInterventionEffect sizeTreatmentPsychoeducationLong-term impactMixed models