2001
α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
Elgoyhen A, Vetter D, Katz E, Rothlin C, Heinemann S, Boulter J. α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 3501-3506. PMID: 11248107, PMCID: PMC30682, DOI: 10.1073/pnas.051622798.Peer-Reviewed Original ResearchConceptsHair cellsMechanosensory hair cellsCholinergic receptor functionAgonist-mediated desensitizationHair cell functionAlpha9 nAChREfferent modulationHeteromeric nAChRsAlpha9alpha10 nAChRsPharmacological profileBiphasic responseMammalian vestibularReceptor functionAlpha10 subunitsNAChRsCell functionAlpha9Xenopus laevis oocytesCurrent-voltage relationshipVertebrate hair cellsSubunit geneLaevis oocytesAlpha10CellsAlpha9alpha10
1999
The α9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A γ-Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors
Rothlin C, Katz E, Verbitsky M, Elgoyhen A. The α9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A γ-Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors. Molecular Pharmacology 1999, 55: 248-254. PMID: 9927615, DOI: 10.1124/mol.55.2.248.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsBariumBicucullineCalciumChelating AgentsDNA, ComplementaryEgtazic AcidFemaleGABA AntagonistsGlycineGlycine AgentsIndolesMembrane PotentialsOocytesReceptors, GABA-AReceptors, GlycineReceptors, NicotinicReceptors, SerotoninReceptors, Serotonin, 5-HT3Recombinant Fusion ProteinsSerotoninSerotonin AntagonistsStrychnineTropisetronXenopus laevisConceptsPharmacological propertiesGamma-aminobutyric acid receptor antagonist bicucullineAlpha9 nicotinic acetylcholine receptorACh-evoked currentsAgonist maximal responseType 3 serotonin receptorReceptor antagonist bicucullineGlycinergic antagonist strychnineGamma-aminobutyric acidNicotinic acetylcholine receptorsSimilar pharmacological propertiesCochlear outer hair cellsOuter hair cellsConcentration-dependent mannerCys-loop familyAlpha9 nAChRAntagonist bicucullineAntagonist strychnineCholinergic receptorsΓ-aminobutyric acidCys-loop receptorsSerotonin receptorsMaximal responseAcetylcholine receptorsHair cells