2024
Measuring GPPGA, Pain, Symptom, and Quality of Life Index Scores in Untreated Generalized Pustular Psoriasis: Results from the Placebo Group of the Effisayil-2 Trial
Strober B, Mostaghimi A, Anadkat M, Thoma C, Tang M, Guercio J, Lebwohl M. Measuring GPPGA, Pain, Symptom, and Quality of Life Index Scores in Untreated Generalized Pustular Psoriasis: Results from the Placebo Group of the Effisayil-2 Trial. SKIN The Journal Of Cutaneous Medicine 2024, 8: s361. DOI: 10.25251/skin.8.supp.361.Peer-Reviewed Original ResearchGeneralized Pustular Psoriasis Physician Global AssessmentGeneralized pustular psoriasis flaresGeneralized pustular psoriasisPsoriasis Symptom ScalePlacebo-treated patientsVisual analog scalePlacebo groupDermatology Quality of Life IndexPain scoresPustular psoriasisPain visual analog scaleQuality of lifeMajority of patientsPhysician global assessmentDisease burdenLife-threatening skin diseaseQuality of Life Index scoreModerate painSevere painSterile pustulesAcute flaresAnalog scaleDisease activityQuality of Life IndexGPP flaresEffect of High-Dose Subcutaneous Spesolimab on Skin Manifestations: Results from the Pivotal Effisayil 2 Trial of Flare Prevention in Generalized Pustular Psoriasis
Strober B, Augustin M, Tada Y, Garg A, Jullien D, Gottlieb A, Gudjonsson J, Hu N, Hofmann P, Thoma C, Marzano A. Effect of High-Dose Subcutaneous Spesolimab on Skin Manifestations: Results from the Pivotal Effisayil 2 Trial of Flare Prevention in Generalized Pustular Psoriasis. SKIN The Journal Of Cutaneous Medicine 2024, 8: s371. DOI: 10.25251/skin.8.supp.371.Peer-Reviewed Original ResearchGeneralized pustular psoriasisProportion of patientsGeneralized pustular psoriasis flaresWeek 4Pustular psoriasisGeneralized Pustular Psoriasis Physician Global AssessmentPhysician global assessmentTotal scoreLife-threatening skin diseaseRandomized controlled trialsPlacebo groupMaintenance doseLoading doseSterile pustulesSkin manifestationsSpesolimabApproved treatmentPlaceboTreatment periodGlobal assessmentPatientsMonoclonal antibodiesTreatment groupsSkin diseasesBaseline scores
2023
The Epidemiology of Palmoplantar Pustulosis: An Analysis of Multiple Health Insurance Claims and Electronic Health Records Databases
Ramcharran D, Strober B, Gordon K, DeKlotz C, Fakharzadeh S, Yang Y, Swerdel J, Hardin J, Dronavalli S, Paller A. The Epidemiology of Palmoplantar Pustulosis: An Analysis of Multiple Health Insurance Claims and Electronic Health Records Databases. Advances In Therapy 2023, 40: 5090-5101. PMID: 37737889, PMCID: PMC10567878, DOI: 10.1007/s12325-023-02669-w.Peer-Reviewed Original ResearchConceptsElectronic health record databaseHealth record databasePPP patientsRecord databaseHigher baseline useChronic inflammatory conditionsPost-diagnosis treatmentHealth insurance claimsConclusionsThe burdenPotential miscodingPalmoplantar pustulosisSterile pustulesBaseline characteristicsMetabolic syndromeBaseline useInflammatory conditionsIncidence ratePopulation-based approachPrevalence estimatesPPP prevalenceEpidemiologyAdditional studiesPustulosisDisease treatmentPatients
2021
Unmet Educational Needs and Clinical Practice Gaps in the Management of Generalized Pustular Psoriasis: Global Perspectives from the Front Line
Strober B, Leman J, Mockenhaupt M, Nakano de Melo J, Nassar A, Prajapati V, Romanelli P, Seneschal J, Tsianakas A, Wei L, Yasuda M, Yu N, Hernandez Daly A, Okubo Y. Unmet Educational Needs and Clinical Practice Gaps in the Management of Generalized Pustular Psoriasis: Global Perspectives from the Front Line. Dermatology And Therapy 2021, 12: 381-393. PMID: 34904208, PMCID: PMC8850517, DOI: 10.1007/s13555-021-00661-2.Peer-Reviewed Original ResearchClinical practice gapsPustular psoriasisRobust clinical trial dataPractice gapConsistent treatment guidelinesPathogenesis of GPPGeneralized pustular psoriasisInconsistent diagnostic criteriaCare of patientsHealthcare system levelClinical trial dataAppropriate treatment initiationAutoinflammatory skin diseaseUnmet educational needsSterile pustulesTreatment guidelinesTreatment initiationRecurrent flaresGeneral practitionersAutoinflammatory diseasesDiagnostic criteriaPatientsSkin diseasesMore experienceMultidisciplinary team