2024
Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma
Lu B, Lucca L, Lewis W, Wang J, Nogueira C, Heer S, Rayon-Estrada V, Axisa P, Reeves S, Buitrago-Pocasangre N, Pham G, Kojima M, Wei W, Aizenbud L, Bacchiocchi A, Zhang L, Walewski J, Chiang V, Olino K, Clune J, Halaban R, Kluger Y, Coyle A, Kisielow J, Obermair F, Kluger H, Hafler D. Circulating tumor-reactive KIR+CD8+ T cells suppress anti-tumor immunity in patients with melanoma. Nature Immunology 2024, 1-10. PMID: 39609626, DOI: 10.1038/s41590-024-02023-4.Peer-Reviewed Original ResearchCD8+ T cellsAnti-tumor immunityRegulatory T cellsT cellsSubpopulation of CD8+ T cellsCytotoxic CD8+ T cellsHuman CD8+ T cellsTumor antigen-specific CD8Impaired anti-tumor immunityTumor antigen-specificPoor overall survivalTumor rejectionKIR expressionOverall survivalTumor antigensImmune evasionCellular mediatorsHuman cancersCD8MelanomaTumorTranscriptional programsFunctional heterogeneityImmunityPatients
2016
Facial manifestations of Epstein–Barr virus‐related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations
Lu B, Kojima L, Huang M, Friedmann A, Ferry J, Weinstein H. Facial manifestations of Epstein–Barr virus‐related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations. Pediatric Blood & Cancer 2016, 63: 2042-2045. PMID: 27392033, DOI: 10.1002/pbc.26102.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaLymphoblastic leukemiaLymphoproliferative diseaseB-cell acute lymphoblastic leukemiaRight-sided facial swellingT-cell acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaHematopoietic transplantationMaintenance chemotherapyPrimary immunodeficiencyBilateral dacryoadenitisAtypical presentationFacial swellingLip lesionsNeither patientLymphoplasmacytic infiltrationT cellsFacial manifestationsFacial lesionsB cellsPatientsDe-escalationRemissionLeukemiaLesionsGenomic Characterization of Poorly Differentiated Neuroendocrine Carcinoma in a Pediatric Patient
Bhatla T, Dandekar S, Lu B, Wang J, Han E, Bitterman D, Jones C, Evensen N, Magid M, Meyer J, Carroll W. Genomic Characterization of Poorly Differentiated Neuroendocrine Carcinoma in a Pediatric Patient. Journal Of Pediatric Hematology/Oncology 2016, 38: e21-e25. PMID: 26558807, PMCID: PMC4681625, DOI: 10.1097/mph.0000000000000463.Peer-Reviewed Original ResearchConceptsNeuroendocrine carcinomaRare tumorPediatric patientsPoor-differentiated neuroendocrine carcinomasMediastinal neuroendocrine carcinomaPrimary neuroendocrine carcinomaStandard treatment approachLack of standardized treatment approachWhole-exome sequencingLOH regionsGenomic characterizationExome sequencingSomatic variantsHRAS geneTumor tissuesMolecular taxonomyGenomic landscapeSomatic mutationsTumorTreatment approachesTherapeutic targetInvestigation of therapeutic targetsCarcinomaPatientsLOH
2014
Ovarian Vein Thrombophlebitis Related to Large Uterine Myoma
Haynes M, Lu B, Winkel A. Ovarian Vein Thrombophlebitis Related to Large Uterine Myoma. Obstetrics And Gynecology 2014, 123: 450-453. PMID: 24413242, DOI: 10.1097/aog.0000000000000091.Peer-Reviewed Original ResearchConceptsOvarian vein thrombophlebitisUterine myomaAbdominal painEvidence of venous stasisLeft ovarian veinSevere abdominal painComputed tomography scanRisk factors of pregnancyFactors of pregnancyNonpuerperal patientsAbdominal myomectomyNulligravid womenEnlarged uterusOvarian veinVenous compressionPostoperative diseaseTomography scanUnusual caseVenous stasisMyomaRisk factorsThrombophlebitisPatientsIntraluminal thrombusThrombosis formation