Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity
Warner-Schmidt J, Pittenger C, Stogniew M, Mandell B, Olmstead S, Kelmendi B. Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity. Frontiers In Psychiatry 2023, 13: 1041277. PMID: 36704743, PMCID: PMC9873307, DOI: 10.3389/fpsyt.2022.1041277.Peer-Reviewed Original ResearchForced Swim TestAntidepressant-like effectsMajor depressive disorderPost-traumatic stress disorderSingle doseAnxiolytic effectsSelective serotonin reuptake inhibitor antidepressantsFirst-line pharmacological treatmentSerotonin reuptake inhibitor antidepressantsAntidepressant-like responsePhase 1 studyDoses of fluoxetineReuptake inhibitor antidepressantsAntidepressant-like activityInitial clinical findingsClinical case seriesOnset of actionDurability of effectMale Sprague-DawleyDose-response relationshipSSRI fluoxetineMost patientsSSRI treatmentInhibitor antidepressantsCase series