1992
P-glycoprotein expression and multidrug resistance in adrenocortical carcinoma.
Flynn S, Murren J, Kirby W, Honig J, Kan L, Kinder B. P-glycoprotein expression and multidrug resistance in adrenocortical carcinoma. Surgery 1992, 112: 981-6. PMID: 1360713.Peer-Reviewed Original ResearchConceptsP-glycoprotein expressionNormal adrenal cortexAdrenocortical carcinomaP-glycoproteinMultidrug resistanceAdrenal cortexCases of ACCStage of diseaseUnrelated chemotherapeutic agentsParaffin-embedded tumorsVariety of neoplasmsEnergy-dependent efflux pumpMost tumor cellsAdjuvant chemotherapyGlycoprotein antibodiesTumor gradeImmunohistochemistry assaysSignificant chemoresistanceSmall seriesMembrane immunoreactivityChemotherapeutic agentsGlycoprotein expressionTumor cellsEfflux pumpsAntibodies
1988
Poorly differentiated ("insular") carcinoma of the thyroid gland: an aggressive subset of differentiated thyroid neoplasms.
Flynn S, Forman B, Stewart A, Kinder B. Poorly differentiated ("insular") carcinoma of the thyroid gland: an aggressive subset of differentiated thyroid neoplasms. Surgery 1988, 104: 963-70. PMID: 3194848.Peer-Reviewed Original ResearchConceptsTotal thyroidectomyInsular carcinomaDisease 1 yearMajority of patientsAggressive clinical courseExternal beam irradiationDifferentiated thyroid neoplasmsEntire neoplasmFocal recurrenceNode dissectionAggressive treatmentClinical courseFatal courseLocal recurrenceDistant metastasisInitial diagnosisDifferentiated carcinomaAggressive subsetTumor necrosisPapillary carcinomaSuch aggressive behaviorThyroid carcinomaInsular componentPatientsCarcinoma