1998
Detection of thyroglobulin, thyroid peroxidase, and RET/PTC1 mRNA transcripts in the peripheral blood of patients with thyroid disease.
Tallini G, Ghossein RA, Emanuel J, Gill J, Kinder B, Dimich AB, Costa J, Robbins R, Burrow GN, Rosai J. Detection of thyroglobulin, thyroid peroxidase, and RET/PTC1 mRNA transcripts in the peripheral blood of patients with thyroid disease. Journal Of Clinical Oncology 1998, 16: 1158-66. PMID: 9508203, DOI: 10.1200/jco.1998.16.3.1158.Peer-Reviewed Original ResearchConceptsReverse transcription-polymerase chain reactionPeripheral bloodThyroid diseaseThyroid carcinomaBenign thyroid nodulesThyroid peroxidaseThyroid nodulesRT-PCR positivityPeripheral blood samplesDiagnosis of carcinomaTranscription-polymerase chain reactionPapillary thyroid carcinomaBenign thyroid lesionsRET/PTC1Cervical lymphInitial surgeryClinical evidenceExtrathyroid extensionNodular hyperplasiaBenign lesionsPatientsCarcinomaBlood collectionMRNA transcriptsThyroid lesions
1988
Poorly differentiated ("insular") carcinoma of the thyroid gland: an aggressive subset of differentiated thyroid neoplasms.
Flynn S, Forman B, Stewart A, Kinder B. Poorly differentiated ("insular") carcinoma of the thyroid gland: an aggressive subset of differentiated thyroid neoplasms. Surgery 1988, 104: 963-70. PMID: 3194848.Peer-Reviewed Original ResearchConceptsTotal thyroidectomyInsular carcinomaDisease 1 yearMajority of patientsAggressive clinical courseExternal beam irradiationDifferentiated thyroid neoplasmsEntire neoplasmFocal recurrenceNode dissectionAggressive treatmentClinical courseFatal courseLocal recurrenceDistant metastasisInitial diagnosisDifferentiated carcinomaAggressive subsetTumor necrosisPapillary carcinomaSuch aggressive behaviorThyroid carcinomaInsular componentPatientsCarcinoma