2012
Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis
Yang W, Rudick C, Hoxha E, Allsop S, Dimitrakoff J, Klumpp D. Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis. American Journal Of Physiology. Renal Physiology 2012, 303: f350-f356. PMID: 22647634, PMCID: PMC3433862, DOI: 10.1152/ajprenal.00077.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCalcium-Calmodulin-Dependent Protein Kinase Type 2CystitisDose-Response Relationship, DrugFemaleHerpesvirus 1, SuidHyperalgesiaImage Processing, Computer-AssistedImmunohistochemistryInjections, SpinalIsoenzymesMiceMice, Inbred C57BLMicroarray AnalysisPelvic PainPhosphorylationPosterior Horn CellsReal-Time Polymerase Chain ReactionRNARNA, MessengerSpinal CordTranscription, GeneticConceptsSacral spinal cordPelvic painNeurogenic cystitisProtein kinase IISpinal cordDorsal hornAssociated with urothelial lesionsChronic bladder inflammatory diseaseDevelopment of pelvic painMurine neurogenic cystitis modelCaMKII inhibitor KN-93Interstitial cystitis/painful bladder syndromeAssociated with pelvic painCa(2+)/calmodulin-dependent protein kinase IIAbductor caudalis dorsalisProgressive pelvic painPostinfection dayKinase IIInhibitor KN-93Pain-signaling pathwaysFemale C57BL/6J miceCa2+/calmodulin-dependent protein kinase IIPostinfection day 2Pelvic/perineal areaCystitis model
2011
The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells
Xu D, Allsop S, Witherspoon S, Snider J, Yeh J, Fiordalisi J, White C, Williams D, Cox A, Baines A. The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Carcinogenesis 2011, 32: 488-495. PMID: 21262926, PMCID: PMC3066419, DOI: 10.1093/carcin/bgr007.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBcl-Associated Death ProteinCarcinoma, Pancreatic DuctalCell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p27HumansNeoplasm InvasivenessPancreatic NeoplasmsPhosphorylationProto-Oncogene ProteinsProto-Oncogene Proteins c-pim-1Proto-Oncogene Proteins p21(ras)Radiation ToleranceRas ProteinsSignal TransductionConceptsShRNA-mediated suppressionK-Ras signalingPim-1 expressionPancreatic ductal adenocarcinoma cell linesPim-1 kinasePro-apoptotic protein BadCell growthOncogenic K-Ras signalingK-rasPim-1 protein levelsCyclin-dependent kinase inhibitor p27Kip1Immortalized cell modelGrowth transformationHuman pancreatic ductal adenocarcinoma cellsCell linesPancreatic ductal adenocarcinomaPim-1Pancreatic ductal adenocarcinoma cell growthMutant K-rasPim-1 activityPim-1 proteinProtein BadOncogenic K-RasPancreatic ductal adenocarcinoma cellsKinase activity