Elevated phase amplitude coupling as a depression biomarker in epilepsy
Young J, Chan A, Jette N, Bender H, Saad A, Saez I, Panov F, Ghatan S, Yoo J, Singh A, Fields M, Marcuse L, Mayberg H. Elevated phase amplitude coupling as a depression biomarker in epilepsy. Epilepsy & Behavior 2024, 152: 109659. PMID: 38301454, PMCID: PMC10923038, DOI: 10.1016/j.yebeh.2024.109659.Peer-Reviewed Original ResearchBeck Depression Inventory-IIPhase-amplitude couplingComorbid depressionAssessment of depressive symptomsBeck Depression Inventory-II scoresAssociated with comorbid depressionAnterior cingulate cortexEpilepsy patientsAmplitude couplingPre-operative assessmentElevated phase-amplitude couplingSpectral powerOrbitofrontal cortexCingulate cortexPrimary depressionCase-control comparisonDepressive symptomsBrain regionsBrain activityDepression biomarkersAdult epilepsy patientsDepressionBrain recordingsPatient studiesTreatment target