2024
Elevated phase amplitude coupling as a depression biomarker in epilepsy
Young J, Chan A, Jette N, Bender H, Saad A, Saez I, Panov F, Ghatan S, Yoo J, Singh A, Fields M, Marcuse L, Mayberg H. Elevated phase amplitude coupling as a depression biomarker in epilepsy. Epilepsy & Behavior 2024, 152: 109659. PMID: 38301454, PMCID: PMC10923038, DOI: 10.1016/j.yebeh.2024.109659.Peer-Reviewed Original ResearchBeck Depression Inventory-IIPhase-amplitude couplingComorbid depressionAssessment of depressive symptomsBeck Depression Inventory-II scoresAssociated with comorbid depressionAnterior cingulate cortexEpilepsy patientsAmplitude couplingPre-operative assessmentElevated phase-amplitude couplingSpectral powerOrbitofrontal cortexCingulate cortexPrimary depressionCase-control comparisonDepressive symptomsBrain regionsBrain activityDepression biomarkersAdult epilepsy patientsDepressionBrain recordingsPatient studiesTreatment target
2021
Utility of 7 tesla MRI brain in 16 “MRI Negative” epilepsy patients and their surgical outcomes
Sharma H, Feldman R, Delman B, Rutland J, Marcuse L, Fields M, Ghatan S, Panov F, Singh A, Balchandani P. Utility of 7 tesla MRI brain in 16 “MRI Negative” epilepsy patients and their surgical outcomes. Epilepsy & Behavior Reports 2021, 15: 100424. PMID: 33521618, PMCID: PMC7820379, DOI: 10.1016/j.ebr.2020.100424.Peer-Reviewed Original ResearchSuspected seizure onset zoneSurgical outcomesImaging findingsEngel I surgical outcomesLesion statusEpilepsy patientsRetrospective chart reviewSeizure onset zoneEngel IEngel outcomesRadiological findingsMRI brainEpileptogenic potentialChart reviewSurgical interventionT-ScanNeurosurgical interventionEpilepsy surgeryNon-lesionalOnset zonePatientsExpert neuroradiologistsT MRINeuroradiologistsLesions
2020
The Sensitivity of Scalp EEG at Detecting Seizures—A Simultaneous Scalp and Stereo EEG Study
Casale M, Marcuse L, Young J, Jette N, Panov F, Bender H, Saad A, Ghotra R, Ghatan S, Singh A, Yoo J, Fields M. The Sensitivity of Scalp EEG at Detecting Seizures—A Simultaneous Scalp and Stereo EEG Study. Journal Of Clinical Neurophysiology 2020, 39: 78-84. PMID: 32925173, PMCID: PMC8290181, DOI: 10.1097/wnp.0000000000000739.Peer-Reviewed Original ResearchConceptsBilateral tonic-clonic seizuresTonic-clonic seizuresSEEG seizuresMRI lesionsSubclinical seizuresScalp EEGDrug-resistant epilepsy patientsStereo-EEG studyStereo-EEG recordingsSimultaneous scalp EEGDetection of FocalNonlesional patientsInterictal abnormalitiesIctal patternsEpilepsy patientsLong-term effectsSeizuresPatientsSimultaneous scalpEEG seizuresScalpAbnormalitiesLonger durationEEG studiesLesions