2021
T cell dysfunction in glioblastoma: a barrier and an opportunity for the development of successful immunotherapies
Jansen JA, Omuro A, Lucca LE. T cell dysfunction in glioblastoma: a barrier and an opportunity for the development of successful immunotherapies. Current Opinion In Neurology 2021, 34: 827-833. PMID: 34569985, PMCID: PMC8595795, DOI: 10.1097/wco.0000000000000988.Peer-Reviewed Original ResearchConceptsT cell dysfunctionTumor-infiltrating T cellsT cellsCell dysfunctionFuture immunotherapy strategiesCervical lymph nodesTumor-derived antigensImmune checkpoint blockadeCentral nervous systemHomeostatic brainSuccessful immunotherapyCheckpoint blockadeImmunotherapy strategiesLymph nodesTumor rejectionImmune surveillanceImmune responseMouse modelBrain tumorsLymphatic drainageNervous systemSolid tumorsDysfunctionSingle-cell RNA sequencingNatural history
2020
The Role of Medical Therapy for Menigniomas
Roque A, Omuro A. The Role of Medical Therapy for Menigniomas. 2020, 201-215. DOI: 10.1007/978-3-030-59558-6_13.Peer-Reviewed Original ResearchSystemic therapyProspective single-arm studyNatural historyCurrent NCCN guidelinesLower relapse rateMajority of patientsSingle-arm studySmall patient populationVaried outcome measuresNCCN guidelinesRefractory meningiomasRepeat surgerySurgical resectionSystemic treatmentLocal therapyMedical therapyProlong survivalRelapse rateSurgical optionsArm studyPatient populationSomatostatin analoguesGrade IGrade IIAntiangiogenic agents