2021
MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis
Zhong C, Min K, Zhao Z, Zhang C, Gao E, Huang Y, Zhang X, Baldini M, Roy R, Yang X, Koch WJ, Bennett AM, Yu J. MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis. Frontiers In Immunology 2021, 12: 790511. PMID: 34992607, PMCID: PMC8724134, DOI: 10.3389/fimmu.2021.790511.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureCardiomegalyCells, CulturedDisease Models, AnimalDual-Specificity PhosphatasesEchocardiographyFibrosisHeartHeart FailureHumansInterleukin-4MacrophagesMaleMAP Kinase Signaling SystemMatrix Metalloproteinase 9MiceMice, KnockoutMyocardiumPhosphorylationPrimary Cell CultureVentricular RemodelingConceptsMitogen-activated protein kinase phosphatase 5Transverse aortic constrictionCardiac fibrosisMMP-9 expressionPressure overloadCardiac hypertrophyPressure overload-induced cardiac fibrosisOverload-induced cardiac fibrosisTAC-induced cardiac hypertrophyExcessive extracellular matrix depositionPro-fibrotic macrophagesCardiac pressure overloadP38 MAPKMatrix metalloproteinase-9Regulation of MMPsProtein kinase phosphatase 5JNK/ERKIL-4 stimulationExtracellular matrix depositionCardiac injuryAortic constrictionMyocardial fibrosisHeart diseaseFibrotic remodelingMetalloproteinase-9
2007
Mitogen-activated protein kinase phosphatase-1 (MKP-1): a critical regulator of innate immune responses
Chi H, Bennett A, Flavell R. Mitogen-activated protein kinase phosphatase-1 (MKP-1): a critical regulator of innate immune responses. Journal Of Organ Dysfunction 2007, 3: 72-81. DOI: 10.1080/17471060601137415.Peer-Reviewed Original ResearchProtein kinase phosphatase-1Kinase phosphatase-1Innate immune responseMKP-1Toll-like receptorsPhosphatase 1Dual-specificity phosphataseImmune responseC-Jun N-terminal kinaseMKP-1 deficiencyN-terminal kinaseIntracellular negative regulatorTranscriptional inductionExcessive innate immune responseNegative regulatorBiochemical activityCritical regulatorMicrobial pathogensPhysiological functionsPro-inflammatory cytokinesP38 MAPKInnate immunityAutoimmune arthritisDendritic cellsInflammatory mediators