2024
Pathologic prostate cancer grade concordance among high-resolution micro-ultrasound, systematic transrectal ultrasound and MRI fusion biopsy
Lokeshwar S, Choksi A, Smani S, Kong V, Sundaresan V, Sutherland R, Brito J, Renzulli J, Sprenkle P, Leapman M. Pathologic prostate cancer grade concordance among high-resolution micro-ultrasound, systematic transrectal ultrasound and MRI fusion biopsy. Urologic Oncology Seminars And Original Investigations 2024 PMID: 39521675, DOI: 10.1016/j.urolonc.2024.10.018.Peer-Reviewed Original ResearchMRI-TRUSMRI-TRUS fusionImage-guided biopsyFusion biopsyGG upgradingTRUS biopsyBiopsy strategyBiopsy typeNo significant differencePathological concordanceBiopsy techniqueHigh-resolution micro-ultrasoundMRI-TRUS fusion biopsyMultivariate logistic-regression analysisMRI fusion biopsySystematic transrectal ultrasoundProstate cancer patientsSignificant differenceMicro-ultrasoundLogistic-regression analysisMultivariable-analysisPathological downgradingPathological upgradingRandomized controlled trialsProstate biopsyAssessing the safety of ureteral stent placement for obstructive urolithiasis in patients during the COVID-19 pandemic
Choksi A, Lokeshwar S, Gardezi M, Hayden C, Khan A, Tran T, Singh D, Motamedinia P, Martin T. Assessing the safety of ureteral stent placement for obstructive urolithiasis in patients during the COVID-19 pandemic. Translational Andrology And Urology 2024, 13: 1814822-1811822. PMID: 39434763, PMCID: PMC11491224, DOI: 10.21037/tau-24-57.Peer-Reviewed Original ResearchRisk factors for Gleason score upgrade from prostate biopsy to radical prostatectomy
Smani S, Sundaresan V, Lokeshwar S, Choksi A, Carbonella J, Brito J, Renzulli J, Sprenkle P, Leapman M. Risk factors for Gleason score upgrade from prostate biopsy to radical prostatectomy. Exploration Of Targeted Anti-tumor Therapy 2024, 5: 981-996. PMID: 39280242, PMCID: PMC11390291, DOI: 10.37349/etat.2024.00259.Peer-Reviewed Original ResearchGleason score upgradingProstate-specific antigenRisk factorsMagnetic resonance imagingRadical prostatectomyScore upgradingAssociated with Gleason score upgradingBiopsy to radical prostatectomyHigher-risk prostate cancerPatients treated with surgeryProstate magnetic resonance imagingClinically localized diseaseGleason grade groupLow-risk diseaseRecognition of risk factorsBody mass indexGleason upgradingFinal pathologyProstate volumeProstate biopsySource of diagnostic uncertaintyBiopsy coresLocalized diseaseProstate cancerInitial managementClassification and Risk Factors for Surgical Site Infections in Radical Cystectomy: A 16-Year Analysis
Lokeshwar S, Choksi A, Smani S, Ip K, Javier-DesLoges J, Rahman S, Leapman M, Martin T, Hesse D. Classification and Risk Factors for Surgical Site Infections in Radical Cystectomy: A 16-Year Analysis. Surgical Infections 2024, 25: 580-585. PMID: 38959160, DOI: 10.1089/sur.2024.107.Peer-Reviewed Original ResearchSurgical site infectionBody mass indexRadical cystectomyCenters for Disease Control and PreventionIndependent risk factorLength of stayRisk factorsAntibiotic agentsSite infectionCenters for Disease Control and Prevention classificationRisk factors of surgical site infectionFactors associated with surgical site infectionFactors of surgical site infectionPredictive of surgical site infectionDeep incision surgical site infectionSurgical site infection predictorsOdds ratioTreatment of surgical site infectionsDeep surgical site infectionPeri-operative characteristicsPeri-operative morbidityCharlson Comorbidity IndexLogistic regression analysisSuperficial incisionalDisease Control and PreventionRisk Factors and Contemporary Management Options for Pain and Discomfort Experienced During a Prostate Biopsy
Diaz G, Webb L, Rabil M, Lokeshwar S, Choksi A, Leapman M, Sprenkle P. Risk Factors and Contemporary Management Options for Pain and Discomfort Experienced During a Prostate Biopsy. Current Urology Reports 2024, 25: 243-252. PMID: 38896314, DOI: 10.1007/s11934-024-01220-w.Peer-Reviewed Original ResearchProstate biopsyRisk factorsEffective pain management strategiesDiagnosed prostate cancerPain management strategiesIn-office proceduresModern management optionsNonadherence to treatmentContemporary management optionsEnhance patient comfortInnovative imaging modalitiesExperience of painFusion biopsyProstate volumePain intensityProstate cancerPain varyPatient ageIncreased painFollow-upIn-officeManagement optionsSurveillance adherenceBiopsyPharmacological analgesicsHF01-10 UROLOGIC EDUCATION AT THE TURN OF THE 20TH CENTURY: A STUDENT’S PERSPECTIVE
Lokeshwar S, Shaheen D, Choksi A, Patel M, Rahman S, Martin T, Hesse D, Leapman M. HF01-10 UROLOGIC EDUCATION AT THE TURN OF THE 20TH CENTURY: A STUDENT’S PERSPECTIVE. Journal Of Urology 2024, 211: e282. DOI: 10.1097/01.ju.0001008828.35887.de.10.Peer-Reviewed Original ResearchMP58-01 A RANDOMIZED CONTROLLED TRIAL OF A FERMENTED SOY BEVERAGE AMONG PATIENTS WITH LOCALIZED PROSTATE CANCER PRIOR TO RADICAL PROSTATECTOMY
Lokeshwar S, Choksi A, Ali A, Weiss T, Reynolds J, Shuch B, Ferencz T, Kyriakides T, Brito J, Renzulli J, Leapman M. MP58-01 A RANDOMIZED CONTROLLED TRIAL OF A FERMENTED SOY BEVERAGE AMONG PATIENTS WITH LOCALIZED PROSTATE CANCER PRIOR TO RADICAL PROSTATECTOMY. Journal Of Urology 2024, 211: e947. DOI: 10.1097/01.ju.0001008852.83523.41.01.Peer-Reviewed Original ResearchMP11-15 SPERMATOCELECTOMY WITH VERSUS WITHOUT EPIDIDYMECTOMY: A SINGLE INSTITUTION EXPERIENCE
Cahill E, Choksi A, Reddy S, Heckscher D, Rotker K, Honig S. MP11-15 SPERMATOCELECTOMY WITH VERSUS WITHOUT EPIDIDYMECTOMY: A SINGLE INSTITUTION EXPERIENCE. Journal Of Urology 2024, 211: e156. DOI: 10.1097/01.ju.0001008564.85995.11.15.Peer-Reviewed Original ResearchSingle Port Bilateral Ureteral Stricture Repair with Buccal Graft
Choksi A, Hayden C, Sterling J. Single Port Bilateral Ureteral Stricture Repair with Buccal Graft. Videourology 2024, 38: 1-2. DOI: 10.1089/vid.2024.0017.Peer-Reviewed Original ResearchRadiation-induced ureteral strictureMid-ureteral strictureBilateral nephrostomy tubesRadiation therapyStricture repairUreteral stentsUreteral strictureSP robotBuccal graftNephrostomy tubeSingle portRemoval of ureteral stentsArchived patient consentBilateral ureteral stricturesSplit-leg tableUreteral stent positioningMinimal complication rateInfra-umbilical incisionPostoperative day 1Right lower quadrantMeasuring approximately 3 cmLysis of adhesionsAnterior abdominal wallMid-ureteric stonesVideo recording/publicationA0305 Pathologic gleason upgrading following high-resolution micro-ultrasound, conventional ultrasound and MRI fusion biopsy techniques: A comparative study
Lokeshwar S, Choksi A, Smani S, Kong V, Sundaresan V, Brito J, Renzulli J, Sprenkle P, Michael M. A0305 Pathologic gleason upgrading following high-resolution micro-ultrasound, conventional ultrasound and MRI fusion biopsy techniques: A comparative study. European Urology 2024, 85: s1101. DOI: 10.1016/s0302-2838(24)00884-4.Peer-Reviewed Original Research
2021
C–X–C Chemokine Receptor Type 4‑Targeted Imaging in Glioblastoma Multiforme Using 64Cu-Radiolabeled Ultrasmall Gold Nanoclusters
Zhang X, Detering L, Sultan D, Heo G, Luehmann H, Taylor S, Choksi A, Rubin J, Liu Y. C–X–C Chemokine Receptor Type 4‑Targeted Imaging in Glioblastoma Multiforme Using 64Cu-Radiolabeled Ultrasmall Gold Nanoclusters. ACS Applied Bio Materials 2021, 5: 235-242. PMID: 35014818, DOI: 10.1021/acsabm.1c01056.Peer-Reviewed Original ResearchConceptsC-X-C chemokine receptor 4C-X-CGlioblastoma multiformePositron emission tomographyAggressive primary malignant brain cancerAssociated with poor patient survivalDifficult-to-treat cancersPET/computed tomography imagingPoor patient survivalChemokine receptor 4GBM mouse modelPositron emission tomography imagingEffective drug deliveryGBM imagingMalignant brain cancerPrimary malignant brain cancerOverall survivalMultimodal treatmentDrug deliveryPatient survivalPoor prognosisTreatment responseTargeted PET imagingRenal clearanceMouse model
2020
Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma
Zhang X, Ye D, Yang L, Yue Y, Sultan D, Pacia C, Pang H, Detering L, Heo G, Luehmann H, Choksi A, Sethi A, Limbrick D, Becher O, Tai Y, Rubin J, Chen H, Liu Y. Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma. ACS Applied Nano Materials 2020, 3: 11129-11134. PMID: 34337344, PMCID: PMC8320805, DOI: 10.1021/acsanm.0c02297.Peer-Reviewed Original ResearchDiffuse intrinsic pontine gliomaBlood-brain tumor barrierIntrinsic pontine gliomaBlood-brain barrierPositron emission tomographyPontine gliomaBrainstem malignancyDelivery of therapeuticsTumor barrierWildtype miceEffective treatmentEmission tomographyFUS treatmentTumorDelivery efficiencyMiceFUS pressureGliomaTreatmentEffective deliveryDeliveryTime-dependent diffusionPET/CTMalignancyFUS
2019
Assessment of Copper Nanoclusters for Accurate in Vivo Tumor Imaging and Potential for Translation
Heo G, Zhao Y, Sultan D, Zhang X, Detering L, Luehmann H, Zhang X, Li R, Choksi A, Sharp S, Levingston S, Primeau T, Reichert D, Sun G, Razani B, Li S, Weilbaecher K, Dehdashti F, Wooley K, Liu Y. Assessment of Copper Nanoclusters for Accurate in Vivo Tumor Imaging and Potential for Translation. ACS Applied Materials & Interfaces 2019, 11: 19669-19678. PMID: 31074257, PMCID: PMC7811435, DOI: 10.1021/acsami.8b22752.Peer-Reviewed Original ResearchConceptsTriple negative breast cancerPatient-derived xenograft mouse modelsNegative breast cancerDetection of malignancyXenograft mouse modelImaging-guided treatmentCopper nanoclustersHuman TNBC tissuesPotential of nanoparticlesBreast cancerMinimal toxicityTumor retentionMouse modelTNBC tissuesTumor biomarkersOff-target effectsClinical translationCancer theranosticsClinical settingTranslational potentialTumor imagingInaccurate diagnosisCancer imagingCancerPotential toxicity