Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma
Zhang X, Ye D, Yang L, Yue Y, Sultan D, Pacia C, Pang H, Detering L, Heo G, Luehmann H, Choksi A, Sethi A, Limbrick D, Becher O, Tai Y, Rubin J, Chen H, Liu Y. Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma. ACS Applied Nano Materials 2020, 3: 11129-11134. PMID: 34337344, PMCID: PMC8320805, DOI: 10.1021/acsanm.0c02297.Peer-Reviewed Original ResearchDiffuse intrinsic pontine gliomaBlood-brain tumor barrierIntrinsic pontine gliomaBlood-brain barrierPositron emission tomographyPontine gliomaBrainstem malignancyDelivery of therapeuticsTumor barrierWildtype miceEffective treatmentEmission tomographyFUS treatmentTumorDelivery efficiencyMiceFUS pressureGliomaTreatmentEffective deliveryDeliveryTime-dependent diffusionPET/CTMalignancyFUS