2022
Cross-platform analysis reveals cellular and molecular landscape of glioblastoma invasion
Chen AT, Xiao Y, Tang X, Baqri M, Gao X, Reschke M, Sheu WC, Long G, Zhou Y, Deng G, Zhang S, Deng Y, Bai Z, Kim D, Huttner A, Kunes R, Günel M, Moliterno J, Saltzman WM, Fan R, Zhou J. Cross-platform analysis reveals cellular and molecular landscape of glioblastoma invasion. Neuro-Oncology 2022, 25: 482-494. PMID: 35901838, PMCID: PMC10013636, DOI: 10.1093/neuonc/noac186.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCell Line, TumorDisease Models, AnimalGene Expression ProfilingGlioblastomaGliomaHumansMiceNeoplasm InvasivenessConceptsCrystallin alpha BTumor invasionGBM invasionHistology samplesMolecular landscapeTreatment of glioblastomaPostoperative recurrenceGBM patientsInvasive glioblastomaResection modelGlioblastomaNon-invasive counterpartsGBM samplesGlioblastoma invasionCD44PatientsInvasionAlpha BCellular levelTranscriptomic featuresRNA sequencing dataRecurrenceHistology stainsLevelsDisease
1996
Heparin-binding secretory transforming gene (hst) facilitates rat lactotrope cell tumorigenesis and induces prolactin gene transcription.
Shimon I, Hüttner A, Said J, Spirina O, Melmed S. Heparin-binding secretory transforming gene (hst) facilitates rat lactotrope cell tumorigenesis and induces prolactin gene transcription. Journal Of Clinical Investigation 1996, 97: 187-195. PMID: 8550832, PMCID: PMC507078, DOI: 10.1172/jci118388.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionFemaleFibroblast Growth Factor 4Fibroblast Growth FactorsGene Expression Regulation, NeoplasticHumansNeoplasm InvasivenessPituitary NeoplasmsProlactinProlactinomaProliferating Cell Nuclear AntigenProto-Oncogene ProteinsProto-OncogenesRatsRats, WistarRecombinant ProteinsRNA, MessengerTranscription, GeneticTumor Cells, CulturedConceptsFibroblast growth factor 4Cell nuclear antigen stainingBasal PRL secretionGrowth hormone releaseDose-dependent increaseRecombinant FGF-4PRL secretionTumor cell culturesProlactin secretionSubcutaneous injectionAutocrine actionHormone releasePituitary cell lineAntigen stainingHuman prolactinomasProlactinoma developmentGH4 cellsHistologic invasivenessTumor growthCell tumorigenesisMRNA expressionPRL synthesisLuciferase reporterPrimary ratPituitary tumorigenesis