2017
Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage
Chang CF, Goods BA, Askenase MH, Hammond MD, Renfroe SC, Steinschneider AF, Landreneau MJ, Ai Y, Beatty HE, da Costa LHA, Mack M, Sheth KN, Greer DM, Huttner A, Coman D, Hyder F, Ghosh S, Rothlin CV, Love JC, Sansing LH. Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage. Journal Of Clinical Investigation 2017, 128: 607-624. PMID: 29251628, PMCID: PMC5785262, DOI: 10.1172/jci95612.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAxl Receptor Tyrosine KinaseBrain InjuriesCerebral HemorrhageC-Mer Tyrosine KinaseErythrocytesHematomaHumansImmunity, InnateInflammationMacrophagesMaleMiceMice, Inbred C57BLMice, TransgenicPhagocytosisPhenotypeProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesSolubilityTreatment OutcomeConceptsMonocyte-derived macrophagesIntracerebral hemorrhageEryptotic erythrocytesNeurological recoveryHematoma clearanceExperimental intracerebral hemorrhageReceptor tyrosine kinase AXLHuman monocyte-derived macrophagesTyrosine kinase AXLICH onsetFunctional outcomeBrain injuryTissue injurySoluble AxlDynamic phenotypic changesAlternative activationPhenotypic changesMacrophage phenotypeIron depositionMurine brainMacrophage responseRestorative functionEfferocytosisMacrophagesEngulfment of erythrocytes
2011
Cortical injury in multiple sclerosis; the role of the immune system
Walker CA, Huttner AJ, O'Connor KC. Cortical injury in multiple sclerosis; the role of the immune system. BMC Neurology 2011, 11: 152. PMID: 22145746, PMCID: PMC3266198, DOI: 10.1186/1471-2377-11-152.Peer-Reviewed Original ResearchConceptsCortical tissue damageMultiple sclerosisWhite matterCerebral cortexTissue damageCortical tissue injuryPresence of inflammationCerebral white matterCortical injuryNeuronal damageCortical damageRobust inflammationCerebral meningesSuch injuriesTissue injuryDisease pathogenesisImmune systemInflammationInjurySclerosisPatientsMeningesCortexMajor siteCurrent knowledge