2023
Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders
Pardo M, Gregorio S, Montalban E, Pujadas L, Elias-Tersa A, Masachs N, Vílchez-Acosta A, Parent A, Auladell C, Girault J, Vila M, Nairn A, Manso Y, Soriano E. Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders. Frontiers In Cellular Neuroscience 2023, 17: 1143319. PMID: 37153634, PMCID: PMC10157100, DOI: 10.3389/fncel.2023.1143319.Peer-Reviewed Original ResearchOverexpression of ReelinReelin levelsNeuropsychiatric disordersExtracellular matrix protein ReelinReelin expression levelsNigrostriatal dopaminergic projectionMedium spiny neuronsFunction mouse modelsHuman psychiatric disordersStriatal parvalbuminStriatal interneuronsStriatal patchesStriatal complexSpiny neuronsDopaminergic projectionsNeuronal compositionMouse modelProtein ReelinImmunohistochemical techniquesPsychiatric disordersBipolar disorderMice exhibitStriatal structuresAdult plasticityBrain development
2018
Striatal Signaling Regulated by the H3R Histamine Receptor in a Mouse Model of tic Pathophysiology
Rapanelli M, Frick L, Jindachomthong K, Xu J, Ohtsu H, Nairn A, Pittenger C. Striatal Signaling Regulated by the H3R Histamine Receptor in a Mouse Model of tic Pathophysiology. Neuroscience 2018, 392: 172-179. PMID: 30278251, PMCID: PMC6204318, DOI: 10.1016/j.neuroscience.2018.09.035.Peer-Reviewed Original ResearchConceptsHDC-KO miceMitogen-activated protein kinaseHistamine receptorsWT animalsDorsal striatumH3R activationTic-like movementsStriatonigral medium spiny neuronsAkt phosphorylationMedium spiny neuronsWild-type miceRare genetic causeHistamine dysregulationAgonist treatmentKO miceSpiny neuronsTic disordersTic pathophysiologyStriatal signalingMouse modelNeuropsychiatric diseasesKO modelRepetitive movementsStriatumMice