2015
Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells
Rela L, Piantanida AP, Bordey A, Greer CA. Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells. Glia 2015, 63: 1646-1659. PMID: 25856239, PMCID: PMC4506201, DOI: 10.1002/glia.22834.Peer-Reviewed Original ResearchConceptsGlial cellsOlfactory nerveAxon growthVoltage-dependent potassium currentsOlfactory Ensheathing CellsSite of injuryGap junction couplingPotassium currentPotassium channelsJunction couplingInward rectifierNerveRectifier channelsCellsPhysiological propertiesLimited knowledgeInjuryOECsMembrane propertiesFascicles
1998
Electrophysiological Properties of Human Astrocytic Tumor Cells In Situ: Enigma of Spiking Glial Cells
Bordey A, Sontheimer H. Electrophysiological Properties of Human Astrocytic Tumor Cells In Situ: Enigma of Spiking Glial Cells. Journal Of Neurophysiology 1998, 79: 2782-2793. PMID: 9582244, DOI: 10.1152/jn.1998.79.5.2782.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAstrocytesAstrocytomaBrain NeoplasmsCarcinomaCell DifferentiationChildChoroid Plexus NeoplasmsDelayed Rectifier Potassium ChannelsHumansIon TransportNeoplasm ProteinsNeoplastic Stem CellsNerve Tissue ProteinsPatch-Clamp TechniquesPotassiumPotassium Channel BlockersPotassium ChannelsPotassium Channels, Inwardly RectifyingPotassium Channels, Voltage-GatedSodium Channel BlockersSodium ChannelsSpinal CordTetraethylammoniumTetrodotoxinConceptsAstrocytoma cellsTumor cellsGlial cellsWhole-cell patch-clamp recordingsCell patch-clamp recordingsAction potential-like responsesOlder pediatric patientsSpinal cord astrocytesHuman astrocytic tumor cellsSensitive sodium currentsGroup of tumorsLow-grade astrocytomasPatch-clamp recordingsOutward potassium currentGlial tumor cellsAstrocytic tumor cellsGeneration of spikesHigh input resistancePeritumoral astrocytesPediatric patientsMicroM Ba2Pilocytic astrocytomaPotassium currentAstrocytesElectrophysiological propertiesExpression of voltage-activated chloride currents in acute slices of human gliomas
Ullrich N, Bordey A, Gillespie GY, Sontheimer H. Expression of voltage-activated chloride currents in acute slices of human gliomas. Neuroscience 1998, 83: 1161-1173. PMID: 9502255, DOI: 10.1016/s0306-4522(97)00456-9.Peer-Reviewed Original ResearchConceptsAcute slicesChloride currentsGlioma cellsGrade tumorsGlial cellsPatient biopsiesWhole-cell patch-clamp recordingsChloride channelsHost glial cellsImplanted glioma cellsPathological tumor gradeLow-grade tumorsHigh-grade tumorsPatch-clamp recordingsSpecific Cl- channelsNormal glial cellsAstrocyte-like cellsShort-term cultureTumor gradePathological gradeSCID miceVoltage-activated sodiumIntracranial injectionPotassium currentExperimental tumors
1997
Postnatal Development of Ionic Currents in Rat Hippocampal Astrocytes In Situ
Bordey A, Sontheimer H. Postnatal Development of Ionic Currents in Rat Hippocampal Astrocytes In Situ. Journal Of Neurophysiology 1997, 78: 461-477. PMID: 9242294, DOI: 10.1152/jn.1997.78.1.461.Peer-Reviewed Original ResearchConceptsHippocampal astrocytesPostnatal developmentCurrent sensitiveGlial cellsWhole-cell patch-clamp recordingsCell patch-clamp recordingsVoltage-activated sodium currentsGlial fibrillary acidic proteinRat hippocampal slicesRat hippocampal astrocytesFibrillary acidic proteinPatch-clamp recordingsOutward potassium currentEarly postnatal developmentIon channel expressionPercentage of cellsSteady-state activationStrong inward rectificationStratum radiatumHippocampal slicesCA1 regionDevelopmental changesPotassium currentChannel expressionEmbryonic rats