Reducing filamin A restores cortical synaptic connectivity and early social communication following cellular mosaicism in ASD pathways.
Binder M, Escobar I, Xu Y, Sokolov A, Zhang L, Bordey A. Reducing filamin A restores cortical synaptic connectivity and early social communication following cellular mosaicism in ASD pathways. Journal Of Neuroscience 2024 PMID: 39164108, DOI: 10.1523/jneurosci.1245-23.2024.Peer-Reviewed Original ResearchPup isolation callsFilamin AIsolation callsAutism spectrum disorderSigns of autism spectrum disorderPyramidal neuronsConstitutively active mutantCommunication deficitsDownstream of ERK1/2MTOR complex 1Actin crosslinkingSynaptic connectionsExpression of RhebSpine densityActive mutantActive RhebCore pathwaysRhebCortical synaptic connectivityCellular mosaicismConstitutively active RhebOne-month-old miceExcitatory synaptic activityNeocortex of miceSocial communication