BDNF Promotes Axon Branching of Retinal Ganglion Cells via miRNA-132 and p250GAP
Marler KJ, Suetterlin P, Dopplapudi A, Rubikaite A, Adnan J, Maiorano NA, Lowe AS, Thompson ID, Pathania M, Bordey A, Fulga T, Van Vactor DL, Hindges R, Drescher U. BDNF Promotes Axon Branching of Retinal Ganglion Cells via miRNA-132 and p250GAP. Journal Of Neuroscience 2014, 34: 969-979. PMID: 24431455, PMCID: PMC3891972, DOI: 10.1523/jneurosci.1910-13.2014.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorRetinal culturesMiRNA-132Neurotrophin brain-derived neurotrophic factorRetinal ganglion cell axonsAxon branchingGanglion cell axonsRetinal ganglion cellsMouse superior colliculusBDNF actionBDNF treatmentNeurotrophic factorRGC axonsTopographic targetingGanglion cellsCell axonsSuperior colliculusExpression of microRNAsTermination zonesP250GAPProtein levelsVertebrate visual systemAxonsUpregulationMap formationGABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity
Young SZ, Lafourcade CA, Platel JC, Lin TV, Bordey A. GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity. Frontiers In Cellular Neuroscience 2014, 8: 10. PMID: 24478632, PMCID: PMC3904109, DOI: 10.3389/fncel.2014.00010.Peer-Reviewed Original ResearchSubventricular zoneStriatal neuronsSVZ cellsCalcium increaseCalcium activityNeurogenic subventricular zoneSource of GABAGABAergic striatal neuronsPatch-clamp recordingsPostnatal subventricular zoneNeural progenitor cellsGABAergic neuronsPostnatal neurogenesisGABAA receptorsGABAAR activationClamp recordingsCalcium imagingStriatal activityNeuronsProgenitor cellsGABAAxonsDepolarizationCellsDendrites