Postembryonic neuronal addition in Zebrafish dorsal root ganglia is regulated by Notch signaling
McGraw HF, Snelson CD, Prendergast A, Suli A, Raible DW. Postembryonic neuronal addition in Zebrafish dorsal root ganglia is regulated by Notch signaling. Neural Development 2012, 7: 23. PMID: 22738203, PMCID: PMC3438120, DOI: 10.1186/1749-8104-7-23.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedGanglia, SpinalGene Expression Regulation, DevelopmentalHomeodomain ProteinsIntracellular Signaling Peptides and ProteinsMembrane ProteinsNerve Tissue ProteinsNeural CrestNeurogenesisNeuronsReceptor, Notch1Signal TransductionZebrafishZebrafish ProteinsConceptsLarval developmentNotch signalingDorsal root gangliaTransgenic zebrafish lineNeural crest migrationLate larval developmentNeural crest cellsFate-mapping experimentsNeuronal additionVertebrate embryosZebrafish lineCellular regulationCrest migrationProgenitor populationsCrest cellsDRG formationRoot gangliaNew neuronsConditional inhibitionProgenitor cellsSignalingDRG neuronsSensory neuronsPopulation of residentsNeuronsThe metalloproteinase inhibitor Reck is essential for zebrafish DRG development
Prendergast A, Linbo TH, Swarts T, Ungos JM, McGraw HF, Krispin S, Weinstein BM, Raible DW. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Development 2012, 139: 1141-1152. PMID: 22296847, PMCID: PMC3283124, DOI: 10.1242/dev.072439.Peer-Reviewed Original ResearchConceptsRECK functionsNeural crestForward genetic screenCell fate specificationMultipotent cell lineagesCell-autonomous fashionCysteine-rich proteinNeural crest cellsSensory neuron formationReversion-inducing cysteine-rich proteinGenetic screenInhibitors of metalloproteinasesFate specificationSensory neuron precursorsCell motilityCrest cellsCell lineagesProper migrationDRG formationDRG developmentNeuron formationMyriad tissuesKazal motifsNeuron precursorsGenes