Reck enables cerebrovascular development by promoting canonical Wnt signaling
Ulrich F, Carretero-Ortega J, Menéndez J, Narvaez C, Sun B, Lancaster E, Pershad V, Trzaska S, Véliz E, Kamei M, Prendergast A, Kidd KR, Shaw KM, Castranova DA, Pham VN, Lo BD, Martin BL, Raible DW, Weinstein BM, Torres-Vázquez J. Reck enables cerebrovascular development by promoting canonical Wnt signaling. Development 2015, 143: 147-159. PMID: 26657775, PMCID: PMC4725199, DOI: 10.1242/dev.123059.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBlood-Brain BarrierBrainCell LineCerebrovascular CirculationEndothelial CellsGPI-Linked ProteinsHuman Umbilical Vein Endothelial CellsHumansMutationNeovascularization, PhysiologicVascular Endothelial Growth Factor AWnt Signaling PathwayZebrafishZebrafish ProteinsConceptsCanonical WntForward genetic screenCysteine-rich proteinBlood-brain barrierVascular endothelial growth factorReversion-inducing cysteine-rich proteinGenetic screenLethal mutantsProper expressionEndothelial cellsInactivating lesionMolecular markersPivotal modulatorCancer biologyCultured endothelial cellsKazal motifsVascular biologyProtective interfaceMutantsBrain blood vesselsEndothelial growth factorWntBBB formationBiologyRECK