2020
Model selection applied to 750 outpatient ICD-9 codes identifies hazards important for all-cause cancer mortality in 2 million veterans with 14 years of follow-up.
McMahon B, Dhaubhadel S, Hengartner N, Danciu I, Janet T, Justice A. Model selection applied to 750 outpatient ICD-9 codes identifies hazards important for all-cause cancer mortality in 2 million veterans with 14 years of follow-up. Journal Of Clinical Oncology 2020, 38: 2053-2053. DOI: 10.1200/jco.2020.38.15_suppl.2053.Peer-Reviewed Original ResearchMedical recordsCause cancer mortalityVeterans' medical recordsChronic airway obstructionCongestive heart failureColon cancer screeningTobacco use disorderPrevalent codesAirway obstructionHeart failureCancer mortalityC-statisticCancer screeningCommon cancerICD9 codesUse disordersSubsequent mortalityClinical practiceColon cancerICD codesMortalityCancer treatmentVeterans AdministrationCancerAdministrationFIB-4 stage of liver fibrosis is associated with incident heart failure with preserved, but not reduced, ejection fraction among people with and without HIV or hepatitis C
So-Armah KA, Lim JK, Re V, Tate JP, Chang CH, Butt AA, Gibert CL, Rimland D, Marconi VC, Goetz MB, Ramachandran V, Brittain E, Long M, Nguyen KL, Rodriguez-Barradas MC, Budoff MJ, Tindle HA, Samet JH, Justice AC, Freiberg MS, Team V. FIB-4 stage of liver fibrosis is associated with incident heart failure with preserved, but not reduced, ejection fraction among people with and without HIV or hepatitis C. Progress In Cardiovascular Diseases 2020, 63: 184-191. PMID: 32068085, PMCID: PMC7278895, DOI: 10.1016/j.pcad.2020.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsFemaleHealth StatusHeart FailureHepatitis CHIV InfectionsHIV Long-Term SurvivorsHumansIncidenceLiver CirrhosisMaleMiddle AgedPrognosisRisk AssessmentRisk FactorsSeverity of Illness IndexStroke VolumeTime FactorsUnited StatesVentricular Function, LeftVeterans HealthViral LoadConceptsType of HFIncident heart failureHeart failureHepatitis C statusAdvanced fibrosisLiver fibrosisEjection fractionHazard ratioC statusVeterans Aging Cohort StudyRisk of HFpEFLast clinic visitReduced ejection fractionAging Cohort StudyLiver fibrosis scoresPrevalent cardiovascular diseaseFirst HF eventProportional hazards modelIncident HFpEFHepatitis CClinic visitsCohort studyPrimary outcomeFibrosis scoreHF events
2018
Bilirubin Is Inversely Associated With Cardiovascular Disease Among HIV‐Positive and HIV‐Negative Individuals in VACS (Veterans Aging Cohort Study)
Marconi VC, Duncan MS, So‐Armah K, Re VL, Lim JK, Butt AA, Goetz MB, Rodriguez‐Barradas M, Alcorn CW, Lennox J, Beckman JA, Justice A, Freiberg M. Bilirubin Is Inversely Associated With Cardiovascular Disease Among HIV‐Positive and HIV‐Negative Individuals in VACS (Veterans Aging Cohort Study). Journal Of The American Heart Association 2018, 7: e007792. PMID: 29720501, PMCID: PMC6015337, DOI: 10.1161/jaha.117.007792.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTotal cardiovascular diseaseIschemic stroke eventsCardiovascular diseaseCVD eventsHeart failureMyocardial infarctionTotal bilirubinElevated bilirubinStroke eventsRisk factorsIncident total CVDBaseline total bilirubinBaseline cardiovascular diseaseIncident CVD eventsHIV-negative individualsProspective cohort studyElevated bilirubin levelsMultiple risk factorsCohort studyCVD riskHazard ratioIschemic strokeHIV-positiveBilirubin levels
2017
Association Between HIV Infection and the Risk of Heart Failure With Reduced Ejection Fraction and Preserved Ejection Fraction in the Antiretroviral Therapy Era: Results From the Veterans Aging Cohort Study
Freiberg MS, Chang CH, Skanderson M, Patterson OV, DuVall SL, Brandt CA, So-Armah KA, Vasan RS, Oursler KA, Gottdiener J, Gottlieb S, Leaf D, Rodriguez-Barradas M, Tracy RP, Gibert CL, Rimland D, Bedimo RJ, Brown ST, Goetz MB, Warner A, Crothers K, Tindle HA, Alcorn C, Bachmann JM, Justice AC, Butt AA. Association Between HIV Infection and the Risk of Heart Failure With Reduced Ejection Fraction and Preserved Ejection Fraction in the Antiretroviral Therapy Era: Results From the Veterans Aging Cohort Study. JAMA Cardiology 2017, 2: 536-546. PMID: 28384660, PMCID: PMC5541383, DOI: 10.1001/jamacardio.2017.0264.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsCase-Control StudiesCD4 Lymphocyte CountCohort StudiesFemaleHeart FailureHIV InfectionsHumansMaleMiddle AgedProportional Hazards ModelsRisk AssessmentRisk FactorsRisk Reduction BehaviorStroke VolumeUnited StatesUnited States Department of Veterans AffairsVeteransViral LoadConceptsRisk of HFrEFHuman immunodeficiency virus (HIV) infectionVeterans Aging Cohort StudyAntiretroviral therapy eraRisk of HFpEFReduced ejection fractionCells/mm3Immunodeficiency virus infectionHeart failureAging Cohort StudyHIV infectionEjection fractionUninfected veteransTherapy eraCohort studyVirus infectionHIV-1 RNA viral loadTime-updated CD4 cell countHIV-specific factorsBaseline cardiovascular diseaseCD4 cell countRNA viral loadCopies/mLRace/ethnicityObservational cohort
2015
Depression and Human Immunodeficiency Virus Infection Are Risk Factors for Incident Heart Failure Among Veterans
White JR, Chang CC, So-Armah KA, Stewart JC, Gupta SK, Butt AA, Gibert CL, Rimland D, Rodriguez-Barradas MC, Leaf DA, Bedimo RJ, Gottdiener JS, Kop WJ, Gottlieb SS, Budoff MJ, Khambaty T, Tindle HA, Justice AC, Freiberg MS. Depression and Human Immunodeficiency Virus Infection Are Risk Factors for Incident Heart Failure Among Veterans. Circulation 2015, 132: 1630-1638. PMID: 26358261, PMCID: PMC4624488, DOI: 10.1161/circulationaha.114.014443.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgingAntidepressive AgentsAnti-HIV AgentsCardiovascular DiseasesComorbidityDepressive Disorder, MajorDiabetes MellitusElectronic Health RecordsEthnicityFemaleFollow-Up StudiesHeart FailureHIV InfectionsHumansHyperlipidemiasIncidenceKidney DiseasesMaleMiddle AgedProspective StudiesRisk FactorsSubstance-Related DisordersUnited StatesVeteransConceptsMajor depressive disorderRisk factorsHuman immunodeficiency virus (HIV) infectionCox proportional hazards modelBaseline antidepressant useIncident HF eventsRisk of HFIncident heart failureImmunodeficiency virus infectionIndependent risk factorCohort Study participantsHeart failure riskProportional hazards modelHF morbidityCommon comorbiditiesIncident HFAntidepressant useHeart failureHIV infectionHIV- participantsPrimary outcomeNinth RevisionHF eventsMedical recordsDepressive disorder
2011
Risk of Heart Failure With Human Immunodeficiency Virus in the Absence of Prior Diagnosis of Coronary Heart Disease
Butt AA, Chang CC, Kuller L, Goetz MB, Leaf D, Rimland D, Gibert CL, Oursler KK, Rodriguez-Barradas MC, Lim J, Kazis LE, Gottlieb S, Justice AC, Freiberg MS. Risk of Heart Failure With Human Immunodeficiency Virus in the Absence of Prior Diagnosis of Coronary Heart Disease. JAMA Internal Medicine 2011, 171: 737-743. PMID: 21518940, PMCID: PMC3687533, DOI: 10.1001/archinternmed.2011.151.Peer-Reviewed Original ResearchConceptsIncident HF eventsHeart failureCoronary heart diseaseCopies/mLRisk factorsHIV infectionHF eventsHeart diseaseHigh riskVeterans Aging Cohort Study Virtual CohortHIV-1 RNA levelsRisk of HFCoronary heart disease eventsHuman immunodeficiency virus (HIV) infectionRNA levelsIncident heart failureOngoing viral replicationRetrospective cohort studyHeart disease eventsImmunodeficiency virus infectionHuman immunodeficiency virusVACS-VCVeteran EnrolleesCohort studyPrior diagnosis
2009
The Payoff Time
Braithwaite RS, Fiellin D, Justice AC. The Payoff Time. Medical Care 2009, 47: 610-617. PMID: 19433991, PMCID: PMC3077952, DOI: 10.1097/mlr.0b013e31819748d5.Peer-Reviewed Original ResearchConceptsCR screeningComorbid illnessesPatient 1Patient 3Colorectal cancer screening decisionsColorectal cancer screening guidelinesCancer screening guidelinesCongestive heart failureInflammatory bowel diseasePrimary care patientsCancer screening decisionsLife expectancyUnnecessary health careBowel diseaseCare patientsHeart failurePatient 2Screening guidelinesLung diseaseClinical guidelinesCurrent guidelinesTypical patientPractice guidelinesGeneral practiceHealth services
2007
A Framework for Tailoring Clinical Guidelines to Comorbidity at the Point of Care
Braithwaite RS, Concato J, Chang CC, Roberts MS, Justice AC. A Framework for Tailoring Clinical Guidelines to Comorbidity at the Point of Care. JAMA Internal Medicine 2007, 167: 2361-2365. PMID: 18039996, PMCID: PMC3460384, DOI: 10.1001/archinte.167.21.2361.Peer-Reviewed Original ResearchConceptsCongestive heart failureHuman immunodeficiency virusComorbidity-adjusted life expectancyColorectal cancer screeningColorectal cancerClinical guidelinesCancer screeningLife expectancyHeart failureComorbidity profilesImmunodeficiency virusPoint of careIndividual patientsPatientsIncremental benefitCancerComorbiditiesWomenMenGuidelinesExpectancyPayoff timeScreeningYearsCare