2017
Risk of liver decompensation with cumulative use of mitochondrial toxic nucleoside analogues in HIV/hepatitis C virus coinfection
Re V, Zeldow B, Kallan MJ, Tate JP, Carbonari DM, Hennessy S, Kostman JR, Lim JK, Goetz MB, Gross R, Justice AC, Roy JA. Risk of liver decompensation with cumulative use of mitochondrial toxic nucleoside analogues in HIV/hepatitis C virus coinfection. Pharmacoepidemiology And Drug Safety 2017, 26: 1172-1181. PMID: 28722244, PMCID: PMC5624832, DOI: 10.1002/pds.4258.Peer-Reviewed Original ResearchConceptsHepatitis C virusHIV/HCV patientsHuman immunodeficiency virusHepatic decompensationAntiretroviral therapyHCV patientsCohort studyHazard ratioHIV/hepatitis C virus (HCV) coinfectionChronic hepatitis C virusHepatitis C virus coinfectionHIV/HCV coinfectionHIV-/HCV-coinfected patientsVeterans Aging Cohort StudyC virus coinfectionChronic hepatic injuryAging Cohort StudyRisk of deathToxic nucleoside analoguesMarginal structural modelsHCV coinfectionLiver decompensationART regimensDecompensation eventsHepatic injuryRisk of Acute Liver Injury With Antiretroviral Therapy by Viral Hepatitis Status
Gowda C, Newcomb CW, Liu Q, Carbonari DM, Lewis JD, Forde KA, Goldberg DS, Reddy KR, Roy JA, Marks AR, Schneider JL, Kostman JR, Tate JP, Lim JK, Justice AC, Goetz MB, Corley DA, Re V. Risk of Acute Liver Injury With Antiretroviral Therapy by Viral Hepatitis Status. Open Forum Infectious Diseases 2017, 4: ofx012. PMID: 28470014, PMCID: PMC5407218, DOI: 10.1093/ofid/ofx012.Peer-Reviewed Original ResearchSevere acute liver injuryAcute liver injuryViral hepatitis statusAntiretroviral therapyHepatitis statusAminotransferase elevationHazard ratioLiver aminotransferasesLiver injuryHigh riskHIV/viral hepatitisKaiser Permanente Northern CaliforniaVeterans Aging Cohort StudyNonnucleoside reverse transcriptase inhibitorAbacavir/lamivudineProtease inhibitor useTenofovir/emtricitabineAging Cohort StudyHuman immunodeficiency virusRisk of hepatotoxicityConfidence intervalsReverse transcriptase inhibitorART initiationCoinfected PatientsART regimens
2016
Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era
Park LS, Tate JP, Sigel K, Rimland D, Crothers K, Gibert C, Rodriguez-Barradas MC, Goetz MB, Bedimo RJ, Brown ST, Justice AC, Dubrow R. Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era. AIDS 2016, 30: 1795-1806. PMID: 27064994, PMCID: PMC4925286, DOI: 10.1097/qad.0000000000001112.Peer-Reviewed Original ResearchConceptsAntiretroviral therapy eraIncidence rateUninfected personsTherapy eraCohort studyCancer incidenceVeterans Aging Cohort StudyImproved immune functionLarge HIV cohortProspective cohort studyCrude incidence rateIncident cancer diagnosisRisk factor prevalenceAging Cohort StudyEvidence-based screeningIncidence rate ratiosIncidence time trendsFuture cancer incidenceTime trendsHIV/AIDSTrend P valueCancer groupingsSpecific cancer typesART regimensHIV care