2015
Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype
Scholl UI, Healy JM, Thiel A, Fonseca AL, Brown TC, Kunstman JW, Horne MJ, Dietrich D, Riemer J, Kücükköylü S, Reimer EN, Reis AC, Goh G, Kristiansen G, Mahajan A, Korah R, Lifton RP, Prasad ML, Carling T. Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype. Clinical Endocrinology 2015, 83: 779-789. PMID: 26252618, PMCID: PMC4995792, DOI: 10.1111/cen.12873.Peer-Reviewed Original ResearchConceptsAldosterone-producing adenomaAdrenal hyperplasiaHyperplastic adrenal glandsUnilateral adrenal hyperplasiaClinical pathological featuresBilateral adrenal hyperplasiaSomatic mutationsNovel somatic mutationsPredominant histologySecondary hypertensionPrimary hyperaldosteronismRetrospective studyAdrenal glandPathological characteristicsMale genderClear cellsCACNA1D mutationsComputed tomographyImportant causeTumorsKCNJ5HyperplasiaAdenomasExome sequencingPathological phenotypes
2013
Parathyroid Localization and Implications for Clinical Management
Kunstman JW, Kirsch JD, Mahajan A, Udelsman R. Parathyroid Localization and Implications for Clinical Management. The Journal Of Clinical Endocrinology & Metabolism 2013, 98: 902-912. PMID: 23345096, DOI: 10.1210/jc.2012-3168.Peer-Reviewed Original ResearchConceptsParathyroid localizationPrimary hyperparathyroidismRadiation exposurePrevalence of hyperparathyroidismInvasive surgical approachExtensive clinical experienceNoninvasive imaging techniquesSignificant radiation exposureParathyroid arteriographySurgical candidatesFocused parathyroidectomyRefractory diseaseParathyroid surgeryParathyroid pathologyPreoperative localizationSurgical approachClinical managementClinical trialsExquisite anatomical detailComputed tomographyClinical experienceNuclear scintigraphyThyroid glandHyperparathyroidismMultidisciplinary collaboration
2011
Parathyroid Four‐Dimensional Computed Tomography: Evaluation of Radiation Dose Exposure During Preoperative Localization of Parathyroid Tumors in Primary Hyperparathyroidism
Mahajan A, Starker LF, Ghita M, Udelsman R, Brink JA, Carling T. Parathyroid Four‐Dimensional Computed Tomography: Evaluation of Radiation Dose Exposure During Preoperative Localization of Parathyroid Tumors in Primary Hyperparathyroidism. World Journal Of Surgery 2011, 36: 1335-1339. PMID: 22146947, DOI: 10.1007/s00268-011-1365-3.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleFour-Dimensional Computed TomographyHumansHyperparathyroidism, PrimaryInfantInfant, NewbornMaleMiddle AgedParathyroid NeoplasmsParathyroidectomyPreoperative CareRadiation DosageRadiopharmaceuticalsTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonYoung AdultConceptsPrimary hyperparathyroidismFour-dimensional computed tomographyParathyroid tumorsPreoperative localizationThyroid cancerComputed tomographyRadiation doseRadiation exposureSingle-photon emission CTMCi of technetiumSex-dependent risk factorsYear old womanThyroid radiation doseRadiation dose exposurePreoperative imaging modalitiesImaging Performance AssessmentPhoton emission CTCT radiation doseRow CT scannerDetector-row CT scannerPHPT patientsInvasive parathyroidectomyRisk factorsOlder womenBackground radiation exposure
2010
4D Parathyroid CT as the Initial Localization Study for Patients with De Novo Primary Hyperparathyroidism
Starker LF, Mahajan A, Björklund P, Sze G, Udelsman R, Carling T. 4D Parathyroid CT as the Initial Localization Study for Patients with De Novo Primary Hyperparathyroidism. Annals Of Surgical Oncology 2010, 18: 1723-1728. PMID: 21184187, DOI: 10.1245/s10434-010-1507-0.Peer-Reviewed Original ResearchConceptsPrimary hyperparathyroidismMultiglandular diseaseParathyroid tumorsIntraoperative parathyroid hormone measurementParathyroid hormone measurementDe novo patientsMajority of patientsPreferred imaging modalityFour-dimensional computed tomographyIntact PTHInvasive parathyroidectomyConsecutive patientsNovo patientsPathologic findingsParathyroid lesionsComputed tomographyHormone measurementsPatientsCorrect quadrantBiochemical measurementsLocalization studiesTumorsS-CaImaging modalitiesHyperparathyroidism